Advances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy

Neoadjuvant therapy has become the standard of care for locally advanced mid-low rectal cancer. Pathological complete response (pCR) can be achieved in 12%â38% of patients. Patients with pCR have the most favorable long-term outcomes. Intensifying neoadjuvant therapy and extending the interval betwe...

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Autores principales:	Jian Cui, Hui Fang, Lin Zhang, Yun-Long Wu, Hai-Zeng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a23294fba1b44d69b6d32fbfc166caec
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spelling	oai:doaj.org-article:a23294fba1b44d69b6d32fbfc166caec2021-12-02T15:50:56ZAdvances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy2095-882X10.1016/j.cdtm.2016.06.001https://doaj.org/article/a23294fba1b44d69b6d32fbfc166caec2016-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X16300299https://doaj.org/toc/2095-882XNeoadjuvant therapy has become the standard of care for locally advanced mid-low rectal cancer. Pathological complete response (pCR) can be achieved in 12%â38% of patients. Patients with pCR have the most favorable long-term outcomes. Intensifying neoadjuvant therapy and extending the interval between termination of neoadjuvant treatment and surgery may increase the pCR rate. Growing evidence has raised the issue of whether local excision or observation rather than radical surgery is an alternative for patients who achieve a clinical complete response after neoadjuvant therapy. Herein, we highlight many of the advances and resultant controversies that are likely to dominate the research agenda for pCR of rectal cancer in the modern era. Keywords: Rectal cancer, Neoadjuvant therapy, Pathological complete response, Local excision, Wait and seeJian CuiHui FangLin ZhangYun-Long WuHai-Zeng ZhangKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 2, Iss 1, Pp 10-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jian Cui Hui Fang Lin Zhang Yun-Long Wu Hai-Zeng Zhang Advances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy
description	Neoadjuvant therapy has become the standard of care for locally advanced mid-low rectal cancer. Pathological complete response (pCR) can be achieved in 12%â38% of patients. Patients with pCR have the most favorable long-term outcomes. Intensifying neoadjuvant therapy and extending the interval between termination of neoadjuvant treatment and surgery may increase the pCR rate. Growing evidence has raised the issue of whether local excision or observation rather than radical surgery is an alternative for patients who achieve a clinical complete response after neoadjuvant therapy. Herein, we highlight many of the advances and resultant controversies that are likely to dominate the research agenda for pCR of rectal cancer in the modern era. Keywords: Rectal cancer, Neoadjuvant therapy, Pathological complete response, Local excision, Wait and see
format	article
author	Jian Cui Hui Fang Lin Zhang Yun-Long Wu Hai-Zeng Zhang
author_facet	Jian Cui Hui Fang Lin Zhang Yun-Long Wu Hai-Zeng Zhang
author_sort	Jian Cui
title	Advances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy
title_short	Advances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy
title_full	Advances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy
title_fullStr	Advances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy
title_full_unstemmed	Advances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy
title_sort	advances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/a23294fba1b44d69b6d32fbfc166caec
work_keys_str_mv	AT jiancui advancesforachievingapathologicalcompleteresponseforrectalcancerafterneoadjuvanttherapy AT huifang advancesforachievingapathologicalcompleteresponseforrectalcancerafterneoadjuvanttherapy AT linzhang advancesforachievingapathologicalcompleteresponseforrectalcancerafterneoadjuvanttherapy AT yunlongwu advancesforachievingapathologicalcompleteresponseforrectalcancerafterneoadjuvanttherapy AT haizengzhang advancesforachievingapathologicalcompleteresponseforrectalcancerafterneoadjuvanttherapy
_version_	1718385650302976000

Advances for achieving a pathological complete response for rectal cancer after neoadjuvant therapy

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