Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism

Bacterial protein FtsZ polymerizes at mid-cell and exhibits treadmilling dynamics, driving the movement of enzymes that synthesize septal peptidoglycan. Here, McCausland et al. combine theoretical modelling with single-molecule imaging of bacteria to show that FtsZ treadmilling drives enzyme movemen...

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Autores principales:	Joshua W. McCausland, Xinxing Yang, Georgia R. Squyres, Zhixin Lyu, Kevin E. Bruce, Melissa M. Lamanna, Bill Söderström, Ethan C. Garner, Malcolm E. Winkler, Jie Xiao, Jian Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a23599fc4d5a4c45aa6e7629aef838ab
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spelling	oai:doaj.org-article:a23599fc4d5a4c45aa6e7629aef838ab2021-12-02T14:16:14ZTreadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism10.1038/s41467-020-20873-y2041-1723https://doaj.org/article/a23599fc4d5a4c45aa6e7629aef838ab2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20873-yhttps://doaj.org/toc/2041-1723Bacterial protein FtsZ polymerizes at mid-cell and exhibits treadmilling dynamics, driving the movement of enzymes that synthesize septal peptidoglycan. Here, McCausland et al. combine theoretical modelling with single-molecule imaging of bacteria to show that FtsZ treadmilling drives enzyme movement via a Brownian ratchet mechanism.Joshua W. McCauslandXinxing YangGeorgia R. SquyresZhixin LyuKevin E. BruceMelissa M. LamannaBill SöderströmEthan C. GarnerMalcolm E. WinklerJie XiaoJian LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joshua W. McCausland Xinxing Yang Georgia R. Squyres Zhixin Lyu Kevin E. Bruce Melissa M. Lamanna Bill Söderström Ethan C. Garner Malcolm E. Winkler Jie Xiao Jian Liu Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism
description	Bacterial protein FtsZ polymerizes at mid-cell and exhibits treadmilling dynamics, driving the movement of enzymes that synthesize septal peptidoglycan. Here, McCausland et al. combine theoretical modelling with single-molecule imaging of bacteria to show that FtsZ treadmilling drives enzyme movement via a Brownian ratchet mechanism.
format	article
author	Joshua W. McCausland Xinxing Yang Georgia R. Squyres Zhixin Lyu Kevin E. Bruce Melissa M. Lamanna Bill Söderström Ethan C. Garner Malcolm E. Winkler Jie Xiao Jian Liu
author_facet	Joshua W. McCausland Xinxing Yang Georgia R. Squyres Zhixin Lyu Kevin E. Bruce Melissa M. Lamanna Bill Söderström Ethan C. Garner Malcolm E. Winkler Jie Xiao Jian Liu
author_sort	Joshua W. McCausland
title	Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism
title_short	Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism
title_full	Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism
title_fullStr	Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism
title_full_unstemmed	Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism
title_sort	treadmilling ftsz polymers drive the directional movement of spg-synthesis enzymes via a brownian ratchet mechanism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a23599fc4d5a4c45aa6e7629aef838ab
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Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism

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