Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation

Abstract Recent studies demonstrated a critical functional connection between the autonomic (sympathetic and parasympathetic) nervous and the immune systems. The carotid sinus nerve (CSN) conveys electrical signals from the chemoreceptors of the carotid bifurcation to the central nervous system wher...

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Autores principales:	Fernanda Machado Santos-Almeida, Gean Domingos-Souza, César A. Meschiari, Laura Campos Fávaro, Christiane Becari, Jaci A. Castania, Alexandre Lopes, Thiago M. Cunha, Davi J. A. Moraes, Fernando Q. Cunha, Luis Ulloa, Alexandre Kanashiro, Geisa C. S. V. Tezini, Helio C. Salgado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a23664769526447d8ebaae9047414149
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spelling	oai:doaj.org-article:a23664769526447d8ebaae90474141492021-12-02T11:53:10ZCarotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation10.1038/s41598-017-06703-02045-2322https://doaj.org/article/a23664769526447d8ebaae90474141492017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06703-0https://doaj.org/toc/2045-2322Abstract Recent studies demonstrated a critical functional connection between the autonomic (sympathetic and parasympathetic) nervous and the immune systems. The carotid sinus nerve (CSN) conveys electrical signals from the chemoreceptors of the carotid bifurcation to the central nervous system where the stimuli are processed to activate sympathetic and parasympathetic efferent signals. Here, we reported that chemoreflex activation via electrical CSN stimulation, in conscious rats, controls the innate immune response to lipopolysaccharide attenuating the plasma levels of inflammatory cytokines such as tumor necrosis factor (TNF), interleukin 1β (IL-1β) and interleukin 6 (IL-6). By contrast, the chemoreflex stimulation increases the plasma levels of anti-inflammatory cytokine interleukin 10 (IL-10). This chemoreflex anti-inflammatory network was abrogated by carotid chemoreceptor denervation and by pharmacological blockade of either sympathetic - propranolol - or parasympathetic - methylatropine – signals. The chemoreflex stimulation as well as the surgical and pharmacological procedures were confirmed by real-time recording of hemodynamic parameters [pulsatile arterial pressure (PAP) and heart rate (HR)]. These results reveal, in conscious animals, a novel mechanism of neuromodulation mediated by the carotid chemoreceptors and involving both the sympathetic and parasympathetic systems.Fernanda Machado Santos-AlmeidaGean Domingos-SouzaCésar A. MeschiariLaura Campos FávaroChristiane BecariJaci A. CastaniaAlexandre LopesThiago M. CunhaDavi J. A. MoraesFernando Q. CunhaLuis UlloaAlexandre KanashiroGeisa C. S. V. TeziniHelio C. SalgadoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fernanda Machado Santos-Almeida Gean Domingos-Souza César A. Meschiari Laura Campos Fávaro Christiane Becari Jaci A. Castania Alexandre Lopes Thiago M. Cunha Davi J. A. Moraes Fernando Q. Cunha Luis Ulloa Alexandre Kanashiro Geisa C. S. V. Tezini Helio C. Salgado Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation
description	Abstract Recent studies demonstrated a critical functional connection between the autonomic (sympathetic and parasympathetic) nervous and the immune systems. The carotid sinus nerve (CSN) conveys electrical signals from the chemoreceptors of the carotid bifurcation to the central nervous system where the stimuli are processed to activate sympathetic and parasympathetic efferent signals. Here, we reported that chemoreflex activation via electrical CSN stimulation, in conscious rats, controls the innate immune response to lipopolysaccharide attenuating the plasma levels of inflammatory cytokines such as tumor necrosis factor (TNF), interleukin 1β (IL-1β) and interleukin 6 (IL-6). By contrast, the chemoreflex stimulation increases the plasma levels of anti-inflammatory cytokine interleukin 10 (IL-10). This chemoreflex anti-inflammatory network was abrogated by carotid chemoreceptor denervation and by pharmacological blockade of either sympathetic - propranolol - or parasympathetic - methylatropine – signals. The chemoreflex stimulation as well as the surgical and pharmacological procedures were confirmed by real-time recording of hemodynamic parameters [pulsatile arterial pressure (PAP) and heart rate (HR)]. These results reveal, in conscious animals, a novel mechanism of neuromodulation mediated by the carotid chemoreceptors and involving both the sympathetic and parasympathetic systems.
format	article
author	Fernanda Machado Santos-Almeida Gean Domingos-Souza César A. Meschiari Laura Campos Fávaro Christiane Becari Jaci A. Castania Alexandre Lopes Thiago M. Cunha Davi J. A. Moraes Fernando Q. Cunha Luis Ulloa Alexandre Kanashiro Geisa C. S. V. Tezini Helio C. Salgado
author_facet	Fernanda Machado Santos-Almeida Gean Domingos-Souza César A. Meschiari Laura Campos Fávaro Christiane Becari Jaci A. Castania Alexandre Lopes Thiago M. Cunha Davi J. A. Moraes Fernando Q. Cunha Luis Ulloa Alexandre Kanashiro Geisa C. S. V. Tezini Helio C. Salgado
author_sort	Fernanda Machado Santos-Almeida
title	Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation
title_short	Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation
title_full	Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation
title_fullStr	Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation
title_full_unstemmed	Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation
title_sort	carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a23664769526447d8ebaae9047414149
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Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation

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