COMPARATIVE CHARACTERISTICS OF IMMUNOLOGICAL RECONSTRUCTION OF WHITE MICE IMMUNIZED BY CELL WALL OF DIFFERENT SUBSPECIES OF FRANCISELLA TULARENSIS

At present, development of effective vaccines of new generation is an actual problem, in particular concerning the tularemia causative agent. It determines the need to search antigen determinants with high immunogenic activity. Some authors demonstrate that outer membrane proteins of Francisella tul...

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Autores principales:	T. P. Starovoitova, V. I. Dubrovina, S. A. Vityazeva, A. V. Korneva, T. A. Ivanova, M. Yu. Kotlov, S. V. Balakhonov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	francisella tularensis tularemia morphometry apudocytes cell wall Science Q
Acceso en línea:	https://doaj.org/article/a238e7ef94b645c782645e66abf892d1
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spelling	oai:doaj.org-article:a238e7ef94b645c782645e66abf892d12021-11-23T06:14:38ZCOMPARATIVE CHARACTERISTICS OF IMMUNOLOGICAL RECONSTRUCTION OF WHITE MICE IMMUNIZED BY CELL WALL OF DIFFERENT SUBSPECIES OF FRANCISELLA TULARENSIS2541-94202587-959610.12737/article_59fad5212be387.98067064https://doaj.org/article/a238e7ef94b645c782645e66abf892d12017-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/422https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596At present, development of effective vaccines of new generation is an actual problem, in particular concerning the tularemia causative agent. It determines the need to search antigen determinants with high immunogenic activity. Some authors demonstrate that outer membrane proteins of Francisella tularensis possess immunological activity. This fact gave occasion to isolation and comprehensive study of F tularensis cellular envelopes as a perspective component in vaccine engineering. The influence of cell walls of F. tularensis was studied for morphological changes in immunocompetent organs of experimental animals. Cell walls were obtained from three virulence strains of living cultures: F. tularensis subsp. mediaasiatica А-61, F. tularensis subsp. nearctica В-399 A-Cole, F. tularensis subsp. holarctica 306 and vaccine strain F. tularensis subsp. holarctica 15 (extracted by Research Institute of Epidemiology and Hygiene). Cell walls of different subspecies of F. tularensis stimulate the production of antibody forming cells and cell proliferation more in T-dependent zones of lymph nodes and spleen. It has been determined that these antigen preparations do not cause stress reaction of the experimental animal organisms. Basing on the findings, we made a conclusion that there is a need for further detailed investigation of immunogenic properties of CE F. tularensis subsp. holarctica 306, F. tularensis subsp. mediasiatica А-61 and F. tularensis subsp. tularensis B-399 A-Cole as perspective components in development of tularemia vaccines.T. P. StarovoitovaV. I. DubrovinaS. A. VityazevaA. V. KornevaT. A. IvanovaM. Yu. KotlovS. V. BalakhonovScientific Сentre for Family Health and Human Reproduction Problemsarticlefrancisella tularensistularemiamorphometryapudocytescell wallmorphometryScienceQRUActa Biomedica Scientifica, Vol 2, Iss 4, Pp 101-106 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	francisella tularensis tularemia morphometry apudocytes cell wall morphometry Science Q
spellingShingle	francisella tularensis tularemia morphometry apudocytes cell wall morphometry Science Q T. P. Starovoitova V. I. Dubrovina S. A. Vityazeva A. V. Korneva T. A. Ivanova M. Yu. Kotlov S. V. Balakhonov COMPARATIVE CHARACTERISTICS OF IMMUNOLOGICAL RECONSTRUCTION OF WHITE MICE IMMUNIZED BY CELL WALL OF DIFFERENT SUBSPECIES OF FRANCISELLA TULARENSIS
description	At present, development of effective vaccines of new generation is an actual problem, in particular concerning the tularemia causative agent. It determines the need to search antigen determinants with high immunogenic activity. Some authors demonstrate that outer membrane proteins of Francisella tularensis possess immunological activity. This fact gave occasion to isolation and comprehensive study of F tularensis cellular envelopes as a perspective component in vaccine engineering. The influence of cell walls of F. tularensis was studied for morphological changes in immunocompetent organs of experimental animals. Cell walls were obtained from three virulence strains of living cultures: F. tularensis subsp. mediaasiatica А-61, F. tularensis subsp. nearctica В-399 A-Cole, F. tularensis subsp. holarctica 306 and vaccine strain F. tularensis subsp. holarctica 15 (extracted by Research Institute of Epidemiology and Hygiene). Cell walls of different subspecies of F. tularensis stimulate the production of antibody forming cells and cell proliferation more in T-dependent zones of lymph nodes and spleen. It has been determined that these antigen preparations do not cause stress reaction of the experimental animal organisms. Basing on the findings, we made a conclusion that there is a need for further detailed investigation of immunogenic properties of CE F. tularensis subsp. holarctica 306, F. tularensis subsp. mediasiatica А-61 and F. tularensis subsp. tularensis B-399 A-Cole as perspective components in development of tularemia vaccines.
format	article
author	T. P. Starovoitova V. I. Dubrovina S. A. Vityazeva A. V. Korneva T. A. Ivanova M. Yu. Kotlov S. V. Balakhonov
author_facet	T. P. Starovoitova V. I. Dubrovina S. A. Vityazeva A. V. Korneva T. A. Ivanova M. Yu. Kotlov S. V. Balakhonov
author_sort	T. P. Starovoitova
title	COMPARATIVE CHARACTERISTICS OF IMMUNOLOGICAL RECONSTRUCTION OF WHITE MICE IMMUNIZED BY CELL WALL OF DIFFERENT SUBSPECIES OF FRANCISELLA TULARENSIS
title_short	COMPARATIVE CHARACTERISTICS OF IMMUNOLOGICAL RECONSTRUCTION OF WHITE MICE IMMUNIZED BY CELL WALL OF DIFFERENT SUBSPECIES OF FRANCISELLA TULARENSIS
title_full	COMPARATIVE CHARACTERISTICS OF IMMUNOLOGICAL RECONSTRUCTION OF WHITE MICE IMMUNIZED BY CELL WALL OF DIFFERENT SUBSPECIES OF FRANCISELLA TULARENSIS
title_fullStr	COMPARATIVE CHARACTERISTICS OF IMMUNOLOGICAL RECONSTRUCTION OF WHITE MICE IMMUNIZED BY CELL WALL OF DIFFERENT SUBSPECIES OF FRANCISELLA TULARENSIS
title_full_unstemmed	COMPARATIVE CHARACTERISTICS OF IMMUNOLOGICAL RECONSTRUCTION OF WHITE MICE IMMUNIZED BY CELL WALL OF DIFFERENT SUBSPECIES OF FRANCISELLA TULARENSIS
title_sort	comparative characteristics of immunological reconstruction of white mice immunized by cell wall of different subspecies of francisella tularensis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/a238e7ef94b645c782645e66abf892d1
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_version_	1718417024054460416

COMPARATIVE CHARACTERISTICS OF IMMUNOLOGICAL RECONSTRUCTION OF WHITE MICE IMMUNIZED BY CELL WALL OF DIFFERENT SUBSPECIES OF FRANCISELLA TULARENSIS

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