White matter hyperintensity in different migraine subtypes

Abstract The diagnostic value of white matter hyperintensities (WMH) in different types of migraineare unknown. To evaluate the WMH pattern of different subtypes in migraine patients with no vascular risk factors. 92 migraine patients (73 females, mean age 34.6 ± 8.9; 61 episodic migraine, 31 chroni...

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Autores principales:	L. A. Dobrynina, A. D. Suslina, M. V. Gubanova, A. V. Belopasova, A. N. Sergeeva, S. Evers, E. V. Gnedovskaya, M. V. Krotenkova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a23970c1084b47279f5e196419e6c3a0
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spelling	oai:doaj.org-article:a23970c1084b47279f5e196419e6c3a02021-12-02T15:49:39ZWhite matter hyperintensity in different migraine subtypes10.1038/s41598-021-90341-02045-2322https://doaj.org/article/a23970c1084b47279f5e196419e6c3a02021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90341-0https://doaj.org/toc/2045-2322Abstract The diagnostic value of white matter hyperintensities (WMH) in different types of migraineare unknown. To evaluate the WMH pattern of different subtypes in migraine patients with no vascular risk factors. 92 migraine patients (73 females, mean age 34.6 ± 8.9; 61 episodic migraine, 31 chronic migraine, 36 migraine with aura, 56 migraine without aura) without vascular risk factors underwent brain MRI (3 T). We also included a matched healthy control group with no migraine (n = 24). The prevalence of WMH in different types of migraine was similar and ranged from 38.7 to 44.4%; the control group showed no WMH at all. Lesions were located within frontal, parietal and temporal lobes (in order of decreasing incidence) in juxtacortical and/or deep white matter. WMH appeared as round or slightly elongated foci with a median size of 2.5 mm [1.5; 3]. Total number, size and prevalence of WMH by lobes and white matter regions were similar between groups, and no interaction with age or sex was found. The number of lesions within the frontal lobe juxtacortical white matter correlated with the age of patients (r = 0.331, p = 0.001) and the duration since migraine onset (r = 0.264, p = 0.012). Patients with different migraine subtypes and without vascular risk factors are characterized by a similar pattern of WMH in the absence of subclinical infarctions or microbleedings. Therefore, WMH have no relevant prognostic value regarding the course of migraine and vascular complications. WMH pattern may be used to differentiate migraine as a primary disorder and other disorders with migraine-like headache and WMH.L. A. DobryninaA. D. SuslinaM. V. GubanovaA. V. BelopasovaA. N. SergeevaS. EversE. V. GnedovskayaM. V. KrotenkovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q L. A. Dobrynina A. D. Suslina M. V. Gubanova A. V. Belopasova A. N. Sergeeva S. Evers E. V. Gnedovskaya M. V. Krotenkova White matter hyperintensity in different migraine subtypes
description	Abstract The diagnostic value of white matter hyperintensities (WMH) in different types of migraineare unknown. To evaluate the WMH pattern of different subtypes in migraine patients with no vascular risk factors. 92 migraine patients (73 females, mean age 34.6 ± 8.9; 61 episodic migraine, 31 chronic migraine, 36 migraine with aura, 56 migraine without aura) without vascular risk factors underwent brain MRI (3 T). We also included a matched healthy control group with no migraine (n = 24). The prevalence of WMH in different types of migraine was similar and ranged from 38.7 to 44.4%; the control group showed no WMH at all. Lesions were located within frontal, parietal and temporal lobes (in order of decreasing incidence) in juxtacortical and/or deep white matter. WMH appeared as round or slightly elongated foci with a median size of 2.5 mm [1.5; 3]. Total number, size and prevalence of WMH by lobes and white matter regions were similar between groups, and no interaction with age or sex was found. The number of lesions within the frontal lobe juxtacortical white matter correlated with the age of patients (r = 0.331, p = 0.001) and the duration since migraine onset (r = 0.264, p = 0.012). Patients with different migraine subtypes and without vascular risk factors are characterized by a similar pattern of WMH in the absence of subclinical infarctions or microbleedings. Therefore, WMH have no relevant prognostic value regarding the course of migraine and vascular complications. WMH pattern may be used to differentiate migraine as a primary disorder and other disorders with migraine-like headache and WMH.
format	article
author	L. A. Dobrynina A. D. Suslina M. V. Gubanova A. V. Belopasova A. N. Sergeeva S. Evers E. V. Gnedovskaya M. V. Krotenkova
author_facet	L. A. Dobrynina A. D. Suslina M. V. Gubanova A. V. Belopasova A. N. Sergeeva S. Evers E. V. Gnedovskaya M. V. Krotenkova
author_sort	L. A. Dobrynina
title	White matter hyperintensity in different migraine subtypes
title_short	White matter hyperintensity in different migraine subtypes
title_full	White matter hyperintensity in different migraine subtypes
title_fullStr	White matter hyperintensity in different migraine subtypes
title_full_unstemmed	White matter hyperintensity in different migraine subtypes
title_sort	white matter hyperintensity in different migraine subtypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a23970c1084b47279f5e196419e6c3a0
work_keys_str_mv	AT ladobrynina whitematterhyperintensityindifferentmigrainesubtypes AT adsuslina whitematterhyperintensityindifferentmigrainesubtypes AT mvgubanova whitematterhyperintensityindifferentmigrainesubtypes AT avbelopasova whitematterhyperintensityindifferentmigrainesubtypes AT ansergeeva whitematterhyperintensityindifferentmigrainesubtypes AT severs whitematterhyperintensityindifferentmigrainesubtypes AT evgnedovskaya whitematterhyperintensityindifferentmigrainesubtypes AT mvkrotenkova whitematterhyperintensityindifferentmigrainesubtypes
_version_	1718385708300763136

White matter hyperintensity in different migraine subtypes

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