Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast

To understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or ecologically diverse isolates of the same species, within a controlled environment. In particular, this approach may lead to understanding mechanisms...

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Autores principales:	Alaattin Kaya, Cheryl Zi Jin Phua, Mitchell Lee, Lu Wang, Alexander Tyshkovskiy, Siming Ma, Benjamin Barre, Weiqiang Liu, Benjamin R Harrison, Xiaqing Zhao, Xuming Zhou, Brian M Wasko, Theo K Bammler, Daniel EL Promislow, Matt Kaeberlein, Vadim N Gladyshev
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	aging natural lifespan variation longevity gene-environment interaction multi-omics yeast Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a23ce55a348841cb82af4f69eb2572cd
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spelling	oai:doaj.org-article:a23ce55a348841cb82af4f69eb2572cd2021-11-30T14:24:53ZEvolution of natural lifespan variation and molecular strategies of extended lifespan in yeast10.7554/eLife.648602050-084Xe64860https://doaj.org/article/a23ce55a348841cb82af4f69eb2572cd2021-11-01T00:00:00Zhttps://elifesciences.org/articles/64860https://doaj.org/toc/2050-084XTo understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or ecologically diverse isolates of the same species, within a controlled environment. In particular, this approach may lead to understanding mechanisms underlying natural variation in lifespan. Here, we analyzed 76 ecologically diverse wild yeast isolates and discovered a wide diversity of replicative lifespan (RLS). Phylogenetic analyses pointed to genes and environmental factors that strongly interact to modulate the observed aging patterns. We then identified genetic networks causally associated with natural variation in RLS across wild yeast isolates, as well as genes, metabolites, and pathways, many of which have never been associated with yeast lifespan in laboratory settings. In addition, a combined analysis of lifespan-associated metabolic and transcriptomic changes revealed unique adaptations to interconnected amino acid biosynthesis, glutamate metabolism, and mitochondrial function in long-lived strains. Overall, our multiomic and lifespan analyses across diverse isolates of the same species shows how gene–environment interactions shape cellular processes involved in phenotypic variation such as lifespan.Alaattin KayaCheryl Zi Jin PhuaMitchell LeeLu WangAlexander TyshkovskiySiming MaBenjamin BarreWeiqiang LiuBenjamin R HarrisonXiaqing ZhaoXuming ZhouBrian M WaskoTheo K BammlerDaniel EL PromislowMatt KaeberleinVadim N GladysheveLife Sciences Publications Ltdarticleagingnatural lifespan variationlongevitygene-environment interactionmulti-omicsyeastMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging natural lifespan variation longevity gene-environment interaction multi-omics yeast Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	aging natural lifespan variation longevity gene-environment interaction multi-omics yeast Medicine R Science Q Biology (General) QH301-705.5 Alaattin Kaya Cheryl Zi Jin Phua Mitchell Lee Lu Wang Alexander Tyshkovskiy Siming Ma Benjamin Barre Weiqiang Liu Benjamin R Harrison Xiaqing Zhao Xuming Zhou Brian M Wasko Theo K Bammler Daniel EL Promislow Matt Kaeberlein Vadim N Gladyshev Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast
description	To understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or ecologically diverse isolates of the same species, within a controlled environment. In particular, this approach may lead to understanding mechanisms underlying natural variation in lifespan. Here, we analyzed 76 ecologically diverse wild yeast isolates and discovered a wide diversity of replicative lifespan (RLS). Phylogenetic analyses pointed to genes and environmental factors that strongly interact to modulate the observed aging patterns. We then identified genetic networks causally associated with natural variation in RLS across wild yeast isolates, as well as genes, metabolites, and pathways, many of which have never been associated with yeast lifespan in laboratory settings. In addition, a combined analysis of lifespan-associated metabolic and transcriptomic changes revealed unique adaptations to interconnected amino acid biosynthesis, glutamate metabolism, and mitochondrial function in long-lived strains. Overall, our multiomic and lifespan analyses across diverse isolates of the same species shows how gene–environment interactions shape cellular processes involved in phenotypic variation such as lifespan.
format	article
author	Alaattin Kaya Cheryl Zi Jin Phua Mitchell Lee Lu Wang Alexander Tyshkovskiy Siming Ma Benjamin Barre Weiqiang Liu Benjamin R Harrison Xiaqing Zhao Xuming Zhou Brian M Wasko Theo K Bammler Daniel EL Promislow Matt Kaeberlein Vadim N Gladyshev
author_facet	Alaattin Kaya Cheryl Zi Jin Phua Mitchell Lee Lu Wang Alexander Tyshkovskiy Siming Ma Benjamin Barre Weiqiang Liu Benjamin R Harrison Xiaqing Zhao Xuming Zhou Brian M Wasko Theo K Bammler Daniel EL Promislow Matt Kaeberlein Vadim N Gladyshev
author_sort	Alaattin Kaya
title	Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast
title_short	Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast
title_full	Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast
title_fullStr	Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast
title_full_unstemmed	Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast
title_sort	evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/a23ce55a348841cb82af4f69eb2572cd
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Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast

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