Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty

Hypothalamic dysfunction is the most common pathology of the puberty and is accompanied by obesity in 39 % of adolescent girls. Obesity is one of the main causes of reproductive function disorders leading to decrease infertility in women. The aim of the study is to assess the gynecological health of...

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Autores principales:	I. V. Zhukovets, O. Ya. Leshchenko, A. V. Atalyan
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	era pgr nf-kв hypothalamic dysfunction nf-kb endometrium primary infertility Science Q
Acceso en línea:	https://doaj.org/article/a2405ad9d0bc4cd9be820e172cbe4090
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spelling	oai:doaj.org-article:a2405ad9d0bc4cd9be820e172cbe40902021-11-23T06:14:38ZBasic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty2541-94202587-959610.12737/article_59e8bd5104ac02.59665046https://doaj.org/article/a2405ad9d0bc4cd9be820e172cbe40902017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/426https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Hypothalamic dysfunction is the most common pathology of the puberty and is accompanied by obesity in 39 % of adolescent girls. Obesity is one of the main causes of reproductive function disorders leading to decrease infertility in women. The aim of the study is to assess the gynecological health of reproductive age women with hypothalamic dysfunction in puberty and to determine the mechanisms of the primary infertility formation. We conducted a prospective study of adolescent girls with hypothalamic dysfunction (n = 170) from 2000 to 2013 year. According to the screening criteria, fertility was assessed in 86 women of reproductive age, a comparative characteristic was performed in fertile women (n = 46) and in women with primary infertility (n = 21). PCOS (38.1 %), absence of ayellow body in one of the ovaries (71.4 %), a decrease in serum progesterone by 2 times, an increase in ERa/PGR by 2.3 times and activity of NF-kB by 1.4 times in the endometrium were detected significantly more often in women with primary infertility with hypothalamic dysfunction in puberty in comparison with fertile women. The level of ERa and PGR in the endometrium decreased with increasing activity of NF-kB and BMI. The relationship between the activity of NF-kB and BMI in both study groups was established.I. V. ZhukovetsO. Ya. LeshchenkoA. V. AtalyanScientific Сentre for Family Health and Human Reproduction Problemsarticleerapgrnf-kвhypothalamic dysfunctionerapgrnf-kbendometriumprimary infertilityScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(1), Pp 15-19 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	era pgr nf-kв hypothalamic dysfunction era pgr nf-kb endometrium primary infertility Science Q
spellingShingle	era pgr nf-kв hypothalamic dysfunction era pgr nf-kb endometrium primary infertility Science Q I. V. Zhukovets O. Ya. Leshchenko A. V. Atalyan Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty
description	Hypothalamic dysfunction is the most common pathology of the puberty and is accompanied by obesity in 39 % of adolescent girls. Obesity is one of the main causes of reproductive function disorders leading to decrease infertility in women. The aim of the study is to assess the gynecological health of reproductive age women with hypothalamic dysfunction in puberty and to determine the mechanisms of the primary infertility formation. We conducted a prospective study of adolescent girls with hypothalamic dysfunction (n = 170) from 2000 to 2013 year. According to the screening criteria, fertility was assessed in 86 women of reproductive age, a comparative characteristic was performed in fertile women (n = 46) and in women with primary infertility (n = 21). PCOS (38.1 %), absence of ayellow body in one of the ovaries (71.4 %), a decrease in serum progesterone by 2 times, an increase in ERa/PGR by 2.3 times and activity of NF-kB by 1.4 times in the endometrium were detected significantly more often in women with primary infertility with hypothalamic dysfunction in puberty in comparison with fertile women. The level of ERa and PGR in the endometrium decreased with increasing activity of NF-kB and BMI. The relationship between the activity of NF-kB and BMI in both study groups was established.
format	article
author	I. V. Zhukovets O. Ya. Leshchenko A. V. Atalyan
author_facet	I. V. Zhukovets O. Ya. Leshchenko A. V. Atalyan
author_sort	I. V. Zhukovets
title	Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty
title_short	Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty
title_full	Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty
title_fullStr	Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty
title_full_unstemmed	Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty
title_sort	basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/a2405ad9d0bc4cd9be820e172cbe4090
work_keys_str_mv	AT ivzhukovets basicmechanismsofprimaryinfertilityinreproductiveagewomenwithhypothalamicdysfunctioninpuberty AT oyaleshchenko basicmechanismsofprimaryinfertilityinreproductiveagewomenwithhypothalamicdysfunctioninpuberty AT avatalyan basicmechanismsofprimaryinfertilityinreproductiveagewomenwithhypothalamicdysfunctioninpuberty
_version_	1718417024296681472

Basic mechanisms of primary infertility in reproductive age women with hypothalamic dysfunction in puberty

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