Nontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century

Abstract Disease caused by nontuberculous mycobacteria (NTM) is reported to increase due to an ageing population and a rise in the proportion of immunosuppressed patients. We did a retrospective cohort study of NTM-disease in the Danish population through a quarter-century to determine the disease b...

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Autores principales:	Thomas S. Hermansen, Pernille Ravn, Erik Svensson, Troels Lillebaek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a242193394da4d8b866317c6bc49bd43
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spelling	oai:doaj.org-article:a242193394da4d8b866317c6bc49bd432021-12-02T16:06:49ZNontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century10.1038/s41598-017-06931-42045-2322https://doaj.org/article/a242193394da4d8b866317c6bc49bd432017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06931-4https://doaj.org/toc/2045-2322Abstract Disease caused by nontuberculous mycobacteria (NTM) is reported to increase due to an ageing population and a rise in the proportion of immunosuppressed patients. We did a retrospective cohort study of NTM-disease in the Danish population through a quarter-century to determine the disease burden and trends in annual incidence rates. 524,119 clinical specimens were cultured for mycobacteria from 1991 through 2015 at the International Reference Laboratory of Mycobacteriology in Denmark. Among these, 8,227 NTM strains were identified from 3,462 patients and distributed according to microbiological disease criteria. We observed no increase in NTM disease incidence or proportion of patients with positive NTM cultures during the study period (Quasi-Poisson regression, p = 0.275 and 0.352 respectively). Annual incidence rates were 1.20/105 for definite NTM disease, 0.49/105 for possible NTM disease and 0.88/105 for NTM colonization. The incidence rate of NTM disease was highest in children aged 0-4 years (5.36/105/year), predominantly with cervical Mycobacterium avium complex (MAC) adenitis. Surprisingly, based on more than half a million clinical specimens cultured for mycobacteria in Denmark through 25 years, the NTM disease burden and trend in incidence in the Danish population has not increased opposed to numerous internationals reports.Thomas S. HermansenPernille RavnErik SvenssonTroels LillebaekNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thomas S. Hermansen Pernille Ravn Erik Svensson Troels Lillebaek Nontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century
description	Abstract Disease caused by nontuberculous mycobacteria (NTM) is reported to increase due to an ageing population and a rise in the proportion of immunosuppressed patients. We did a retrospective cohort study of NTM-disease in the Danish population through a quarter-century to determine the disease burden and trends in annual incidence rates. 524,119 clinical specimens were cultured for mycobacteria from 1991 through 2015 at the International Reference Laboratory of Mycobacteriology in Denmark. Among these, 8,227 NTM strains were identified from 3,462 patients and distributed according to microbiological disease criteria. We observed no increase in NTM disease incidence or proportion of patients with positive NTM cultures during the study period (Quasi-Poisson regression, p = 0.275 and 0.352 respectively). Annual incidence rates were 1.20/105 for definite NTM disease, 0.49/105 for possible NTM disease and 0.88/105 for NTM colonization. The incidence rate of NTM disease was highest in children aged 0-4 years (5.36/105/year), predominantly with cervical Mycobacterium avium complex (MAC) adenitis. Surprisingly, based on more than half a million clinical specimens cultured for mycobacteria in Denmark through 25 years, the NTM disease burden and trend in incidence in the Danish population has not increased opposed to numerous internationals reports.
format	article
author	Thomas S. Hermansen Pernille Ravn Erik Svensson Troels Lillebaek
author_facet	Thomas S. Hermansen Pernille Ravn Erik Svensson Troels Lillebaek
author_sort	Thomas S. Hermansen
title	Nontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century
title_short	Nontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century
title_full	Nontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century
title_fullStr	Nontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century
title_full_unstemmed	Nontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century
title_sort	nontuberculous mycobacteria in denmark, incidence and clinical importance during the last quarter-century
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a242193394da4d8b866317c6bc49bd43
work_keys_str_mv	AT thomasshermansen nontuberculousmycobacteriaindenmarkincidenceandclinicalimportanceduringthelastquartercentury AT pernilleravn nontuberculousmycobacteriaindenmarkincidenceandclinicalimportanceduringthelastquartercentury AT eriksvensson nontuberculousmycobacteriaindenmarkincidenceandclinicalimportanceduringthelastquartercentury AT troelslillebaek nontuberculousmycobacteriaindenmarkincidenceandclinicalimportanceduringthelastquartercentury
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Nontuberculous mycobacteria in Denmark, incidence and clinical importance during the last quarter-century

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