Association between metabolic syndrome and incidence of ocular motor nerve palsy

Abstract To assess the association between metabolic syndrome (MetS) and the development of third, fourth, and sixth cranial nerve palsy (CNP). Health checkup data of 4,067,842 individuals aged between 20 and 90 years provided by the National Health Insurance Service (NHIS) of South Korea between Ja...

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Autores principales:	Daye Diana Choi, Kyungdo Han, Sei Yeul Oh, Kyung-Ah Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a2482c422c944211a3cff044f7b47dc7
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spelling	oai:doaj.org-article:a2482c422c944211a3cff044f7b47dc72021-12-05T12:14:44ZAssociation between metabolic syndrome and incidence of ocular motor nerve palsy10.1038/s41598-021-02517-32045-2322https://doaj.org/article/a2482c422c944211a3cff044f7b47dc72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02517-3https://doaj.org/toc/2045-2322Abstract To assess the association between metabolic syndrome (MetS) and the development of third, fourth, and sixth cranial nerve palsy (CNP). Health checkup data of 4,067,842 individuals aged between 20 and 90 years provided by the National Health Insurance Service (NHIS) of South Korea between January 1, 2009, and December 31, 2009, were analyzed. Participants were followed up to December 31, 2017. Hazard ratio (HR) and 95% confidence interval (CI) of CNP were estimated using Cox proportional hazards regression analysis after adjusting for potential confounders. Model 1 included only incident CNP as a time-varying covariate. Model 2 included model 1 and individual’s age and sex. Model 3 included model 2, smoking status, alcohol consumption, and physical activity of individuals. We identified 5,835 incident CNP cases during the follow-up period (8.22 ± 0.94 years). Individuals with MetS (n = 851,004) showed an increased risk of CNP compared to individuals without MetS (n = 3,216,838) after adjustment (model 3: HR = 1.35, 95% CI 1.273–1.434). CNP incidence was positively correlated with the number of MetS components (log-rank p < 0.0001). The HR of CNP for males with MetS compared to males without MetS was higher than that of females with MetS compared to females without MetS (HR: 1.407, 95% CI 1.31–1.51 in men and HR: 1.259, 95% CI 1.13–1.40 in women, p for interaction = 0.0017). Our population-based large-scale cohort study suggests that MetS and its components might be risk factors for CNP development.Daye Diana ChoiKyungdo HanSei Yeul OhKyung-Ah ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daye Diana Choi Kyungdo Han Sei Yeul Oh Kyung-Ah Park Association between metabolic syndrome and incidence of ocular motor nerve palsy
description	Abstract To assess the association between metabolic syndrome (MetS) and the development of third, fourth, and sixth cranial nerve palsy (CNP). Health checkup data of 4,067,842 individuals aged between 20 and 90 years provided by the National Health Insurance Service (NHIS) of South Korea between January 1, 2009, and December 31, 2009, were analyzed. Participants were followed up to December 31, 2017. Hazard ratio (HR) and 95% confidence interval (CI) of CNP were estimated using Cox proportional hazards regression analysis after adjusting for potential confounders. Model 1 included only incident CNP as a time-varying covariate. Model 2 included model 1 and individual’s age and sex. Model 3 included model 2, smoking status, alcohol consumption, and physical activity of individuals. We identified 5,835 incident CNP cases during the follow-up period (8.22 ± 0.94 years). Individuals with MetS (n = 851,004) showed an increased risk of CNP compared to individuals without MetS (n = 3,216,838) after adjustment (model 3: HR = 1.35, 95% CI 1.273–1.434). CNP incidence was positively correlated with the number of MetS components (log-rank p < 0.0001). The HR of CNP for males with MetS compared to males without MetS was higher than that of females with MetS compared to females without MetS (HR: 1.407, 95% CI 1.31–1.51 in men and HR: 1.259, 95% CI 1.13–1.40 in women, p for interaction = 0.0017). Our population-based large-scale cohort study suggests that MetS and its components might be risk factors for CNP development.
format	article
author	Daye Diana Choi Kyungdo Han Sei Yeul Oh Kyung-Ah Park
author_facet	Daye Diana Choi Kyungdo Han Sei Yeul Oh Kyung-Ah Park
author_sort	Daye Diana Choi
title	Association between metabolic syndrome and incidence of ocular motor nerve palsy
title_short	Association between metabolic syndrome and incidence of ocular motor nerve palsy
title_full	Association between metabolic syndrome and incidence of ocular motor nerve palsy
title_fullStr	Association between metabolic syndrome and incidence of ocular motor nerve palsy
title_full_unstemmed	Association between metabolic syndrome and incidence of ocular motor nerve palsy
title_sort	association between metabolic syndrome and incidence of ocular motor nerve palsy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2482c422c944211a3cff044f7b47dc7
work_keys_str_mv	AT dayedianachoi associationbetweenmetabolicsyndromeandincidenceofocularmotornervepalsy AT kyungdohan associationbetweenmetabolicsyndromeandincidenceofocularmotornervepalsy AT seiyeuloh associationbetweenmetabolicsyndromeandincidenceofocularmotornervepalsy AT kyungahpark associationbetweenmetabolicsyndromeandincidenceofocularmotornervepalsy
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Association between metabolic syndrome and incidence of ocular motor nerve palsy

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