Rational design of aptamer switches with programmable pH response

Previous design strategies for pH sensitive aptamers were not readily tunable across pH ranges. Here the authors present a general method to convert aptamers into pH-responsive switches using two orthogonal motifs.

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Autores principales:	Ian A. P. Thompson, Liwei Zheng, Michael Eisenstein, H. Tom Soh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a24a2adf9c434bc799e6e407a56532c7
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spelling	oai:doaj.org-article:a24a2adf9c434bc799e6e407a56532c72021-12-02T17:47:59ZRational design of aptamer switches with programmable pH response10.1038/s41467-020-16808-22041-1723https://doaj.org/article/a24a2adf9c434bc799e6e407a56532c72020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16808-2https://doaj.org/toc/2041-1723Previous design strategies for pH sensitive aptamers were not readily tunable across pH ranges. Here the authors present a general method to convert aptamers into pH-responsive switches using two orthogonal motifs.Ian A. P. ThompsonLiwei ZhengMichael EisensteinH. Tom SohNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ian A. P. Thompson Liwei Zheng Michael Eisenstein H. Tom Soh Rational design of aptamer switches with programmable pH response
description	Previous design strategies for pH sensitive aptamers were not readily tunable across pH ranges. Here the authors present a general method to convert aptamers into pH-responsive switches using two orthogonal motifs.
format	article
author	Ian A. P. Thompson Liwei Zheng Michael Eisenstein H. Tom Soh
author_facet	Ian A. P. Thompson Liwei Zheng Michael Eisenstein H. Tom Soh
author_sort	Ian A. P. Thompson
title	Rational design of aptamer switches with programmable pH response
title_short	Rational design of aptamer switches with programmable pH response
title_full	Rational design of aptamer switches with programmable pH response
title_fullStr	Rational design of aptamer switches with programmable pH response
title_full_unstemmed	Rational design of aptamer switches with programmable pH response
title_sort	rational design of aptamer switches with programmable ph response
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a24a2adf9c434bc799e6e407a56532c7
work_keys_str_mv	AT ianapthompson rationaldesignofaptamerswitcheswithprogrammablephresponse AT liweizheng rationaldesignofaptamerswitcheswithprogrammablephresponse AT michaeleisenstein rationaldesignofaptamerswitcheswithprogrammablephresponse AT htomsoh rationaldesignofaptamerswitcheswithprogrammablephresponse
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Rational design of aptamer switches with programmable pH response

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