Rational design of aptamer switches with programmable pH response

Previous design strategies for pH sensitive aptamers were not readily tunable across pH ranges. Here the authors present a general method to convert aptamers into pH-responsive switches using two orthogonal motifs.

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Autores principales: Ian A. P. Thompson, Liwei Zheng, Michael Eisenstein, H. Tom Soh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a24a2adf9c434bc799e6e407a56532c7
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