Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia

Emergence of ABL1 kinase inhibitor resistant clones may cause disease relapse in Philadelphia chromosome-positive acute lymphoblastic leukemia. Here, the authors show interleukin 7 receptor (IL7R) signaling to contribute to this resistance mechanism, and that targeting the IL7R pathway may suppress...

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Autores principales: Hend Abdelrasoul, Anila Vadakumchery, Markus Werner, Lennart Lenk, Ahmad Khadour, Marc Young, Omar El Ayoubi, Fotini Vogiatzi, Markus Krämer, Vera Schmid, Zhengshan Chen, Yasar Yousafzai, Gunnar Cario, Martin Schrappe, Markus Müschen, Christina Halsey, Medhanie A. Mulaw, Denis M. Schewe, Elias Hobeika, Ameera Alsadeq, Hassan Jumaa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a25003f7a49e4b7f9022e8001e0418c9
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spelling oai:doaj.org-article:a25003f7a49e4b7f9022e8001e0418c92021-12-02T17:45:00ZSynergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia10.1038/s41467-020-16927-w2041-1723https://doaj.org/article/a25003f7a49e4b7f9022e8001e0418c92020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16927-whttps://doaj.org/toc/2041-1723Emergence of ABL1 kinase inhibitor resistant clones may cause disease relapse in Philadelphia chromosome-positive acute lymphoblastic leukemia. Here, the authors show interleukin 7 receptor (IL7R) signaling to contribute to this resistance mechanism, and that targeting the IL7R pathway may suppress incurable drug-resistant leukemia forms.Hend AbdelrasoulAnila VadakumcheryMarkus WernerLennart LenkAhmad KhadourMarc YoungOmar El AyoubiFotini VogiatziMarkus KrämerVera SchmidZhengshan ChenYasar YousafzaiGunnar CarioMartin SchrappeMarkus MüschenChristina HalseyMedhanie A. MulawDenis M. ScheweElias HobeikaAmeera AlsadeqHassan JumaaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hend Abdelrasoul
Anila Vadakumchery
Markus Werner
Lennart Lenk
Ahmad Khadour
Marc Young
Omar El Ayoubi
Fotini Vogiatzi
Markus Krämer
Vera Schmid
Zhengshan Chen
Yasar Yousafzai
Gunnar Cario
Martin Schrappe
Markus Müschen
Christina Halsey
Medhanie A. Mulaw
Denis M. Schewe
Elias Hobeika
Ameera Alsadeq
Hassan Jumaa
Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia
description Emergence of ABL1 kinase inhibitor resistant clones may cause disease relapse in Philadelphia chromosome-positive acute lymphoblastic leukemia. Here, the authors show interleukin 7 receptor (IL7R) signaling to contribute to this resistance mechanism, and that targeting the IL7R pathway may suppress incurable drug-resistant leukemia forms.
format article
author Hend Abdelrasoul
Anila Vadakumchery
Markus Werner
Lennart Lenk
Ahmad Khadour
Marc Young
Omar El Ayoubi
Fotini Vogiatzi
Markus Krämer
Vera Schmid
Zhengshan Chen
Yasar Yousafzai
Gunnar Cario
Martin Schrappe
Markus Müschen
Christina Halsey
Medhanie A. Mulaw
Denis M. Schewe
Elias Hobeika
Ameera Alsadeq
Hassan Jumaa
author_facet Hend Abdelrasoul
Anila Vadakumchery
Markus Werner
Lennart Lenk
Ahmad Khadour
Marc Young
Omar El Ayoubi
Fotini Vogiatzi
Markus Krämer
Vera Schmid
Zhengshan Chen
Yasar Yousafzai
Gunnar Cario
Martin Schrappe
Markus Müschen
Christina Halsey
Medhanie A. Mulaw
Denis M. Schewe
Elias Hobeika
Ameera Alsadeq
Hassan Jumaa
author_sort Hend Abdelrasoul
title Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia
title_short Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia
title_full Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia
title_fullStr Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia
title_full_unstemmed Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia
title_sort synergism between il7r and cxcr4 drives bcr-abl induced transformation in philadelphia chromosome-positive acute lymphoblastic leukemia
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/a25003f7a49e4b7f9022e8001e0418c9
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