SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.

Myeloid blood cells are largely resistant to infection with human immunodeficiency virus type 1 (HIV-1). Recently, it was reported that Vpx from HIV-2/SIVsm facilitates infection of these cells by counteracting the host restriction factor SAMHD1. Here, we independently confirmed that Vpx interacts w...

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Autores principales: André Berger, Andreas F R Sommer, Jenny Zwarg, Matthias Hamdorf, Karin Welzel, Nicole Esly, Sylvia Panitz, Andreas Reuter, Irene Ramos, Asavari Jatiani, Lubbertus C F Mulder, Ana Fernandez-Sesma, Frank Rutsch, Viviana Simon, Renate König, Egbert Flory
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/a25138a23dde4fd5b01d7754d13c5a24
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