Topical rebamipide improves lid wiper epitheliopathy

Hirotaka Itakura,1,2 Tomoyuki Kashima,2 Mariko Itakura,1 Hideo Akiyama,2 Shoji Kishi2 1Department of Ophthalmology, Maebashi Red Cross Hospital, 2Department of Ophthalmology, Gunma University, School of Medicine, Maebashi, Japan Abstract: Administration of topical rebamipide increases the mucin leve...

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Autores principales:	Itakura H, Kashima T, Itakura M, Akiyama H, Kishi S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a25181b067be4202a55da57ca01f6acb
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spelling	oai:doaj.org-article:a25181b067be4202a55da57ca01f6acb2021-12-02T01:23:38ZTopical rebamipide improves lid wiper epitheliopathy1177-54671177-5483https://doaj.org/article/a25181b067be4202a55da57ca01f6acb2013-10-01T00:00:00Zhttp://www.dovepress.com/topical-rebamipide-improves-lid-wiper-epitheliopathy-a14848https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Hirotaka Itakura,1,2 Tomoyuki Kashima,2 Mariko Itakura,1 Hideo Akiyama,2 Shoji Kishi2 1Department of Ophthalmology, Maebashi Red Cross Hospital, 2Department of Ophthalmology, Gunma University, School of Medicine, Maebashi, Japan Abstract: Administration of topical rebamipide increases the mucin level of tear film and improves the ocular surface in short break-up time type of dry eye. Lid wiper epitheliopathy (LWE) is a disorder of the marginal conjunctiva of the upper eyelid with dry eye symptoms. LWE may be related to mechanical forces during blinking resulting in inflammation of the ocular surface. Rebamipide also has various anti-inflammatory effects. In this report, we tried treatment with topical rebamipide for two cases of LWE. One case had been treated with sodium hyaluronate ophthalmic solution and diquafosol sodium eye drops by other doctors for several weeks. The other case was not previously treated. In both cases, fluorescein staining of the cornea and lid margin was remarkably improved, ocular symptoms decreased, and tear film break-up times increased with rebamipide eye drops four times daily for 2–3 weeks. Topical rebamipide was effective for corneal and conjunctival disorders in LWE. This drug may provide a novel approach to the treatment of LWE. Keywords: corneal erosion, dry eye, lid wiper, Mucosta®, mucin, rebamipideItakura HKashima TItakura MAkiyama HKishi SDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 2137-2141 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Itakura H Kashima T Itakura M Akiyama H Kishi S Topical rebamipide improves lid wiper epitheliopathy
description	Hirotaka Itakura,1,2 Tomoyuki Kashima,2 Mariko Itakura,1 Hideo Akiyama,2 Shoji Kishi2 1Department of Ophthalmology, Maebashi Red Cross Hospital, 2Department of Ophthalmology, Gunma University, School of Medicine, Maebashi, Japan Abstract: Administration of topical rebamipide increases the mucin level of tear film and improves the ocular surface in short break-up time type of dry eye. Lid wiper epitheliopathy (LWE) is a disorder of the marginal conjunctiva of the upper eyelid with dry eye symptoms. LWE may be related to mechanical forces during blinking resulting in inflammation of the ocular surface. Rebamipide also has various anti-inflammatory effects. In this report, we tried treatment with topical rebamipide for two cases of LWE. One case had been treated with sodium hyaluronate ophthalmic solution and diquafosol sodium eye drops by other doctors for several weeks. The other case was not previously treated. In both cases, fluorescein staining of the cornea and lid margin was remarkably improved, ocular symptoms decreased, and tear film break-up times increased with rebamipide eye drops four times daily for 2–3 weeks. Topical rebamipide was effective for corneal and conjunctival disorders in LWE. This drug may provide a novel approach to the treatment of LWE. Keywords: corneal erosion, dry eye, lid wiper, Mucosta®, mucin, rebamipide
format	article
author	Itakura H Kashima T Itakura M Akiyama H Kishi S
author_facet	Itakura H Kashima T Itakura M Akiyama H Kishi S
author_sort	Itakura H
title	Topical rebamipide improves lid wiper epitheliopathy
title_short	Topical rebamipide improves lid wiper epitheliopathy
title_full	Topical rebamipide improves lid wiper epitheliopathy
title_fullStr	Topical rebamipide improves lid wiper epitheliopathy
title_full_unstemmed	Topical rebamipide improves lid wiper epitheliopathy
title_sort	topical rebamipide improves lid wiper epitheliopathy
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/a25181b067be4202a55da57ca01f6acb
work_keys_str_mv	AT itakurah topicalrebamipideimproveslidwiperepitheliopathy AT kashimat topicalrebamipideimproveslidwiperepitheliopathy AT itakuram topicalrebamipideimproveslidwiperepitheliopathy AT akiyamah topicalrebamipideimproveslidwiperepitheliopathy AT kishis topicalrebamipideimproveslidwiperepitheliopathy
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Topical rebamipide improves lid wiper epitheliopathy

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