Steering surface topographies of electrospun fibers: understanding the mechanisms

Abstract A profound understanding of how to tailor surface topographies of electrospun fibers is of great importance for surface sensitive applications including optical sensing, catalysis, drug delivery and tissue engineering. Hereby, a novel approach to comprehend the driving forces for fiber surf...

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Autores principales:	Gökçe Yazgan, Ruslan I. Dmitriev, Vasundhara Tyagi, James Jenkins, Gelu-Marius Rotaru, Markus Rottmar, René M. Rossi, Claudio Toncelli, Dmitri B. Papkovsky, Katharina Maniura-Weber, Giuseppino Fortunato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a251e24e44cf4c98b0b322d9be8c482b
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spelling	oai:doaj.org-article:a251e24e44cf4c98b0b322d9be8c482b2021-12-02T12:32:59ZSteering surface topographies of electrospun fibers: understanding the mechanisms10.1038/s41598-017-00181-02045-2322https://doaj.org/article/a251e24e44cf4c98b0b322d9be8c482b2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00181-0https://doaj.org/toc/2045-2322Abstract A profound understanding of how to tailor surface topographies of electrospun fibers is of great importance for surface sensitive applications including optical sensing, catalysis, drug delivery and tissue engineering. Hereby, a novel approach to comprehend the driving forces for fiber surface topography formation is introduced through inclusion of the dynamic solvent-polymer interaction during fiber formation. Thus, the interplay between polymer solubility as well as computed fiber jet surface temperature changes in function of time during solvent evaporation and the resultant phase separation behavior are studied. The correlation of experimental and theoretical results shows that the temperature difference between the polymer solution jet surface temperature and the dew point of the controlled electrospinning environment are the main influencing factors with respect to water condensation and thus phase separation leading to the final fiber surface topography. As polymer matrices with enhanced surface area are particularly appealing for sensing applications, we further functionalized our nanoporous fibrous membranes with a phosphorescent oxygen-sensitive dye. The hybrid membranes possess high brightness, stability in aqueous medium, linear response to oxygen and hence represent a promising scaffold for cell growth, contactless monitoring of oxygen and live fluorescence imaging in 3-D cell models.Gökçe YazganRuslan I. DmitrievVasundhara TyagiJames JenkinsGelu-Marius RotaruMarkus RottmarRené M. RossiClaudio ToncelliDmitri B. PapkovskyKatharina Maniura-WeberGiuseppino FortunatoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gökçe Yazgan Ruslan I. Dmitriev Vasundhara Tyagi James Jenkins Gelu-Marius Rotaru Markus Rottmar René M. Rossi Claudio Toncelli Dmitri B. Papkovsky Katharina Maniura-Weber Giuseppino Fortunato Steering surface topographies of electrospun fibers: understanding the mechanisms
description	Abstract A profound understanding of how to tailor surface topographies of electrospun fibers is of great importance for surface sensitive applications including optical sensing, catalysis, drug delivery and tissue engineering. Hereby, a novel approach to comprehend the driving forces for fiber surface topography formation is introduced through inclusion of the dynamic solvent-polymer interaction during fiber formation. Thus, the interplay between polymer solubility as well as computed fiber jet surface temperature changes in function of time during solvent evaporation and the resultant phase separation behavior are studied. The correlation of experimental and theoretical results shows that the temperature difference between the polymer solution jet surface temperature and the dew point of the controlled electrospinning environment are the main influencing factors with respect to water condensation and thus phase separation leading to the final fiber surface topography. As polymer matrices with enhanced surface area are particularly appealing for sensing applications, we further functionalized our nanoporous fibrous membranes with a phosphorescent oxygen-sensitive dye. The hybrid membranes possess high brightness, stability in aqueous medium, linear response to oxygen and hence represent a promising scaffold for cell growth, contactless monitoring of oxygen and live fluorescence imaging in 3-D cell models.
format	article
author	Gökçe Yazgan Ruslan I. Dmitriev Vasundhara Tyagi James Jenkins Gelu-Marius Rotaru Markus Rottmar René M. Rossi Claudio Toncelli Dmitri B. Papkovsky Katharina Maniura-Weber Giuseppino Fortunato
author_facet	Gökçe Yazgan Ruslan I. Dmitriev Vasundhara Tyagi James Jenkins Gelu-Marius Rotaru Markus Rottmar René M. Rossi Claudio Toncelli Dmitri B. Papkovsky Katharina Maniura-Weber Giuseppino Fortunato
author_sort	Gökçe Yazgan
title	Steering surface topographies of electrospun fibers: understanding the mechanisms
title_short	Steering surface topographies of electrospun fibers: understanding the mechanisms
title_full	Steering surface topographies of electrospun fibers: understanding the mechanisms
title_fullStr	Steering surface topographies of electrospun fibers: understanding the mechanisms
title_full_unstemmed	Steering surface topographies of electrospun fibers: understanding the mechanisms
title_sort	steering surface topographies of electrospun fibers: understanding the mechanisms
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a251e24e44cf4c98b0b322d9be8c482b
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Steering surface topographies of electrospun fibers: understanding the mechanisms

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