Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

Induced pluripotent stem cell (iPSC) derived dopaminergic neurons are a promising source for cell-based Parkinson’s disease (PD) therapy. Here the authors report a comprehensive pre-clinical evaluation of the safety and efficacy of dopaminergic progenitors derived from a clinical-grade human iPSC li...

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Autores principales:	Daisuke Doi, Hiroaki Magotani, Tetsuhiro Kikuchi, Megumi Ikeda, Satoe Hiramatsu, Kenji Yoshida, Naoki Amano, Masaki Nomura, Masafumi Umekage, Asuka Morizane, Jun Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a254d73774aa46918b7ca259baa03c3a
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spelling	oai:doaj.org-article:a254d73774aa46918b7ca259baa03c3a2021-12-02T15:23:00ZPre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease10.1038/s41467-020-17165-w2041-1723https://doaj.org/article/a254d73774aa46918b7ca259baa03c3a2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17165-whttps://doaj.org/toc/2041-1723Induced pluripotent stem cell (iPSC) derived dopaminergic neurons are a promising source for cell-based Parkinson’s disease (PD) therapy. Here the authors report a comprehensive pre-clinical evaluation of the safety and efficacy of dopaminergic progenitors derived from a clinical-grade human iPSC line.Daisuke DoiHiroaki MagotaniTetsuhiro KikuchiMegumi IkedaSatoe HiramatsuKenji YoshidaNaoki AmanoMasaki NomuraMasafumi UmekageAsuka MorizaneJun TakahashiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daisuke Doi Hiroaki Magotani Tetsuhiro Kikuchi Megumi Ikeda Satoe Hiramatsu Kenji Yoshida Naoki Amano Masaki Nomura Masafumi Umekage Asuka Morizane Jun Takahashi Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
description	Induced pluripotent stem cell (iPSC) derived dopaminergic neurons are a promising source for cell-based Parkinson’s disease (PD) therapy. Here the authors report a comprehensive pre-clinical evaluation of the safety and efficacy of dopaminergic progenitors derived from a clinical-grade human iPSC line.
format	article
author	Daisuke Doi Hiroaki Magotani Tetsuhiro Kikuchi Megumi Ikeda Satoe Hiramatsu Kenji Yoshida Naoki Amano Masaki Nomura Masafumi Umekage Asuka Morizane Jun Takahashi
author_facet	Daisuke Doi Hiroaki Magotani Tetsuhiro Kikuchi Megumi Ikeda Satoe Hiramatsu Kenji Yoshida Naoki Amano Masaki Nomura Masafumi Umekage Asuka Morizane Jun Takahashi
author_sort	Daisuke Doi
title	Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
title_short	Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
title_full	Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
title_fullStr	Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
title_full_unstemmed	Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
title_sort	pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for parkinson’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a254d73774aa46918b7ca259baa03c3a
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Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

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