The Association between Galectin-3 and hs-CRP and the Clinical Outcome after Non-ST-Elevation Myocardial Infarction with Preexisting Atrial Fibrillation
Abstract Increased galectin-3 plasma concentration has been linked to an unfavorable outcome in patients with heart failure or atrial fibrillation (AF). There are no published data about the prognostic utility of galectin-3 and high-sensitivity C-reactive protein (hs-CRP) for long-term clinical outc...
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Nature Portfolio
2017
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oai:doaj.org-article:a25522139e604c12a66fa61232782ca52021-12-02T15:06:20ZThe Association between Galectin-3 and hs-CRP and the Clinical Outcome after Non-ST-Elevation Myocardial Infarction with Preexisting Atrial Fibrillation10.1038/s41598-017-15265-02045-2322https://doaj.org/article/a25522139e604c12a66fa61232782ca52017-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-15265-0https://doaj.org/toc/2045-2322Abstract Increased galectin-3 plasma concentration has been linked to an unfavorable outcome in patients with heart failure or atrial fibrillation (AF). There are no published data about the prognostic utility of galectin-3 and high-sensitivity C-reactive protein (hs-CRP) for long-term clinical outcome in the Non-ST elevation acute myocardial infarction (NSTEMI) patients with preexisting AF. Thirty-two patients with the first acute NSTEMI and preexisting AF and 22 patients without preexisting AF, were prospectively followed for fifteen months. Patients with AF had significantly higher galectin-3 plasma levels (p < 0.05) and hs-CRP concentration (p < 0.01), compared with patients without AF. Galectin-3 plasma concentration was not a significant covariate of the composite outcomes (p = 0.913). Patients with high hs-CRP (above 4.55 mg/L) showed 2.5 times increased risk (p < 0.05) of the composite outcome occurrence (p < 0.05). Besides, three-vessel coronary artery disease, creatinine serum level, and creatinine clearance were significant covariates (p < 0.05; p < 0.05; p < 0.01) of the composite outcome, respectively. Creatinine clearance, solely, has been shown to be an independent predictor of unfavorable prognosis after a 15-month follow-up. Galectin-3 and hs-CRP plasma levels were elevated in NSTEMI patients with AF, but with differential predictive value for an unfavorable clinical outcome. Only hs-CRP was associated with increased risk of composite outcome occurrence.Milan PavlovićSvetlana ApostolovićDragana StokanovićStefan MomčilovićTatjana Jevtović-StoimenovSnezana Ćirić ZdravkovićSonja Šalinger MartinovićNebojsa KrstićGoran KoraćevićDanijela DjordjevicVladan ĆosićValentina N. NikolicNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
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Medicine R Science Q Milan Pavlović Svetlana Apostolović Dragana Stokanović Stefan Momčilović Tatjana Jevtović-Stoimenov Snezana Ćirić Zdravković Sonja Šalinger Martinović Nebojsa Krstić Goran Koraćević Danijela Djordjevic Vladan Ćosić Valentina N. Nikolic The Association between Galectin-3 and hs-CRP and the Clinical Outcome after Non-ST-Elevation Myocardial Infarction with Preexisting Atrial Fibrillation |
| description |
Abstract Increased galectin-3 plasma concentration has been linked to an unfavorable outcome in patients with heart failure or atrial fibrillation (AF). There are no published data about the prognostic utility of galectin-3 and high-sensitivity C-reactive protein (hs-CRP) for long-term clinical outcome in the Non-ST elevation acute myocardial infarction (NSTEMI) patients with preexisting AF. Thirty-two patients with the first acute NSTEMI and preexisting AF and 22 patients without preexisting AF, were prospectively followed for fifteen months. Patients with AF had significantly higher galectin-3 plasma levels (p < 0.05) and hs-CRP concentration (p < 0.01), compared with patients without AF. Galectin-3 plasma concentration was not a significant covariate of the composite outcomes (p = 0.913). Patients with high hs-CRP (above 4.55 mg/L) showed 2.5 times increased risk (p < 0.05) of the composite outcome occurrence (p < 0.05). Besides, three-vessel coronary artery disease, creatinine serum level, and creatinine clearance were significant covariates (p < 0.05; p < 0.05; p < 0.01) of the composite outcome, respectively. Creatinine clearance, solely, has been shown to be an independent predictor of unfavorable prognosis after a 15-month follow-up. Galectin-3 and hs-CRP plasma levels were elevated in NSTEMI patients with AF, but with differential predictive value for an unfavorable clinical outcome. Only hs-CRP was associated with increased risk of composite outcome occurrence. |
| format |
article |
| author |
Milan Pavlović Svetlana Apostolović Dragana Stokanović Stefan Momčilović Tatjana Jevtović-Stoimenov Snezana Ćirić Zdravković Sonja Šalinger Martinović Nebojsa Krstić Goran Koraćević Danijela Djordjevic Vladan Ćosić Valentina N. Nikolic |
| author_facet |
Milan Pavlović Svetlana Apostolović Dragana Stokanović Stefan Momčilović Tatjana Jevtović-Stoimenov Snezana Ćirić Zdravković Sonja Šalinger Martinović Nebojsa Krstić Goran Koraćević Danijela Djordjevic Vladan Ćosić Valentina N. Nikolic |
| author_sort |
Milan Pavlović |
| title |
The Association between Galectin-3 and hs-CRP and the Clinical Outcome after Non-ST-Elevation Myocardial Infarction with Preexisting Atrial Fibrillation |
| title_short |
The Association between Galectin-3 and hs-CRP and the Clinical Outcome after Non-ST-Elevation Myocardial Infarction with Preexisting Atrial Fibrillation |
| title_full |
The Association between Galectin-3 and hs-CRP and the Clinical Outcome after Non-ST-Elevation Myocardial Infarction with Preexisting Atrial Fibrillation |
| title_fullStr |
The Association between Galectin-3 and hs-CRP and the Clinical Outcome after Non-ST-Elevation Myocardial Infarction with Preexisting Atrial Fibrillation |
| title_full_unstemmed |
The Association between Galectin-3 and hs-CRP and the Clinical Outcome after Non-ST-Elevation Myocardial Infarction with Preexisting Atrial Fibrillation |
| title_sort |
association between galectin-3 and hs-crp and the clinical outcome after non-st-elevation myocardial infarction with preexisting atrial fibrillation |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a25522139e604c12a66fa61232782ca5 |
| work_keys_str_mv |
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