A Gastric Pathogen Moves Chemotaxis in a New Direction

ABSTRACT For almost 50 years, Escherichia coli has been the model for understanding how bacteria orient their movement in response to chemical cues, but recent studies of chemotaxis in other bacteria have revealed interesting variations from prevailing paradigms. Investigating the human pathogen Hel...

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Autores principales:	Emily Goers Sweeney, Karen Guillemin
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2011
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a2552e0c417f4b68b78e7b592b176e63
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spelling	oai:doaj.org-article:a2552e0c417f4b68b78e7b592b176e632021-11-15T15:38:58ZA Gastric Pathogen Moves Chemotaxis in a New Direction10.1128/mBio.00201-112150-7511https://doaj.org/article/a2552e0c417f4b68b78e7b592b176e632011-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00201-11https://doaj.org/toc/2150-7511ABSTRACT For almost 50 years, Escherichia coli has been the model for understanding how bacteria orient their movement in response to chemical cues, but recent studies of chemotaxis in other bacteria have revealed interesting variations from prevailing paradigms. Investigating the human pathogen Helicobacter pylori, Amieva and colleagues [mBio 2(4):e00098-11, 2011] discovered a new chemotaxis regulator, ChePep, which modulates swimming behavior through the canonical histidine-aspartate phosphorelay system. Functionally conserved among the epsilonproteobacteria, ChePep is essential for H. pylori to navigate deep into the stomach’s gastric glands and may be an attractive target for novel antibiotics.Emily Goers SweeneyKaren GuilleminAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 2, Iss 5 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Emily Goers Sweeney Karen Guillemin A Gastric Pathogen Moves Chemotaxis in a New Direction
description	ABSTRACT For almost 50 years, Escherichia coli has been the model for understanding how bacteria orient their movement in response to chemical cues, but recent studies of chemotaxis in other bacteria have revealed interesting variations from prevailing paradigms. Investigating the human pathogen Helicobacter pylori, Amieva and colleagues [mBio 2(4):e00098-11, 2011] discovered a new chemotaxis regulator, ChePep, which modulates swimming behavior through the canonical histidine-aspartate phosphorelay system. Functionally conserved among the epsilonproteobacteria, ChePep is essential for H. pylori to navigate deep into the stomach’s gastric glands and may be an attractive target for novel antibiotics.
format	article
author	Emily Goers Sweeney Karen Guillemin
author_facet	Emily Goers Sweeney Karen Guillemin
author_sort	Emily Goers Sweeney
title	A Gastric Pathogen Moves Chemotaxis in a New Direction
title_short	A Gastric Pathogen Moves Chemotaxis in a New Direction
title_full	A Gastric Pathogen Moves Chemotaxis in a New Direction
title_fullStr	A Gastric Pathogen Moves Chemotaxis in a New Direction
title_full_unstemmed	A Gastric Pathogen Moves Chemotaxis in a New Direction
title_sort	gastric pathogen moves chemotaxis in a new direction
publisher	American Society for Microbiology
publishDate	2011
url	https://doaj.org/article/a2552e0c417f4b68b78e7b592b176e63
work_keys_str_mv	AT emilygoerssweeney agastricpathogenmoveschemotaxisinanewdirection AT karenguillemin agastricpathogenmoveschemotaxisinanewdirection AT emilygoerssweeney gastricpathogenmoveschemotaxisinanewdirection AT karenguillemin gastricpathogenmoveschemotaxisinanewdirection
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A Gastric Pathogen Moves Chemotaxis in a New Direction

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