Variant antigen diversity in Trypanosoma vivax is not driven by recombination

Variant antigen diversity in Trypanosoma vivax is not driven by recombination

Trypanosoma rely on variant surface glycoprotein (VSG) to escape host immunity, but mechanisms generating antigenic diversity of VSG are poorly understood. Here, Silva-Pereira et al. show that T. vivax has a limited antigenic repertoire compared to T. brucei and that recombination plays little role...

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Detalles Bibliográficos
Autores principales: Sara Silva Pereira, Kayo J. G. de Almeida Castilho Neto, Craig W. Duffy, Peter Richards, Harry Noyes, Moses Ogugo, Marcos Rogério André, Zakaria Bengaly, Steve Kemp, Marta M. G. Teixeira, Rosangela Z. Machado, Andrew P. Jackson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/a256b8b60abb41049cc82d1a6b1db3ac
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Sumario:Trypanosoma rely on variant surface glycoprotein (VSG) to escape host immunity, but mechanisms generating antigenic diversity of VSG are poorly understood. Here, Silva-Pereira et al. show that T. vivax has a limited antigenic repertoire compared to T. brucei and that recombination plays little role in diversifying T. vivax VSG sequences.

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