Variant antigen diversity in Trypanosoma vivax is not driven by recombination

Trypanosoma rely on variant surface glycoprotein (VSG) to escape host immunity, but mechanisms generating antigenic diversity of VSG are poorly understood. Here, Silva-Pereira et al. show that T. vivax has a limited antigenic repertoire compared to T. brucei and that recombination plays little role...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sara Silva Pereira, Kayo J. G. de Almeida Castilho Neto, Craig W. Duffy, Peter Richards, Harry Noyes, Moses Ogugo, Marcos Rogério André, Zakaria Bengaly, Steve Kemp, Marta M. G. Teixeira, Rosangela Z. Machado, Andrew P. Jackson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a256b8b60abb41049cc82d1a6b1db3ac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a256b8b60abb41049cc82d1a6b1db3ac
record_format	dspace
spelling	oai:doaj.org-article:a256b8b60abb41049cc82d1a6b1db3ac2021-12-02T16:49:15ZVariant antigen diversity in Trypanosoma vivax is not driven by recombination10.1038/s41467-020-14575-82041-1723https://doaj.org/article/a256b8b60abb41049cc82d1a6b1db3ac2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14575-8https://doaj.org/toc/2041-1723Trypanosoma rely on variant surface glycoprotein (VSG) to escape host immunity, but mechanisms generating antigenic diversity of VSG are poorly understood. Here, Silva-Pereira et al. show that T. vivax has a limited antigenic repertoire compared to T. brucei and that recombination plays little role in diversifying T. vivax VSG sequences.Sara Silva PereiraKayo J. G. de Almeida Castilho NetoCraig W. DuffyPeter RichardsHarry NoyesMoses OgugoMarcos Rogério AndréZakaria BengalySteve KempMarta M. G. TeixeiraRosangela Z. MachadoAndrew P. JacksonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara Silva Pereira Kayo J. G. de Almeida Castilho Neto Craig W. Duffy Peter Richards Harry Noyes Moses Ogugo Marcos Rogério André Zakaria Bengaly Steve Kemp Marta M. G. Teixeira Rosangela Z. Machado Andrew P. Jackson Variant antigen diversity in Trypanosoma vivax is not driven by recombination
description	Trypanosoma rely on variant surface glycoprotein (VSG) to escape host immunity, but mechanisms generating antigenic diversity of VSG are poorly understood. Here, Silva-Pereira et al. show that T. vivax has a limited antigenic repertoire compared to T. brucei and that recombination plays little role in diversifying T. vivax VSG sequences.
format	article
author	Sara Silva Pereira Kayo J. G. de Almeida Castilho Neto Craig W. Duffy Peter Richards Harry Noyes Moses Ogugo Marcos Rogério André Zakaria Bengaly Steve Kemp Marta M. G. Teixeira Rosangela Z. Machado Andrew P. Jackson
author_facet	Sara Silva Pereira Kayo J. G. de Almeida Castilho Neto Craig W. Duffy Peter Richards Harry Noyes Moses Ogugo Marcos Rogério André Zakaria Bengaly Steve Kemp Marta M. G. Teixeira Rosangela Z. Machado Andrew P. Jackson
author_sort	Sara Silva Pereira
title	Variant antigen diversity in Trypanosoma vivax is not driven by recombination
title_short	Variant antigen diversity in Trypanosoma vivax is not driven by recombination
title_full	Variant antigen diversity in Trypanosoma vivax is not driven by recombination
title_fullStr	Variant antigen diversity in Trypanosoma vivax is not driven by recombination
title_full_unstemmed	Variant antigen diversity in Trypanosoma vivax is not driven by recombination
title_sort	variant antigen diversity in trypanosoma vivax is not driven by recombination
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a256b8b60abb41049cc82d1a6b1db3ac
work_keys_str_mv	AT sarasilvapereira variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination AT kayojgdealmeidacastilhoneto variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination AT craigwduffy variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination AT peterrichards variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination AT harrynoyes variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination AT mosesogugo variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination AT marcosrogerioandre variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination AT zakariabengaly variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination AT stevekemp variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination AT martamgteixeira variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination AT rosangelazmachado variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination AT andrewpjackson variantantigendiversityintrypanosomavivaxisnotdrivenbyrecombination
_version_	1718383413210120192

Variant antigen diversity in Trypanosoma vivax is not driven by recombination

Ejemplares similares