TNFα PRODUCTION AND APOPTOSIS REGULATION IN VIRAL HEPATITIS TYPE C

Abstract. Chronical course of infection caused by hepatitis C virus is accompanied by increase Fas-positive lymphocytes of peripheral blood. Cultivation of agglutinin-stimulated mononuclear blood cells of patients with chronic hepatitis C revealed inhibition of apoptotic reactions of blood lymphocyt...

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Autores principales:	V. V. Novitsky, N. V. Rjazantseva, O. B. Zhukova, T. T. Radzivil, E. V. Beloborodova, A. P. Zima, I. O. Naslednikova, M. M. Litvak, S. L. Mikheev
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	hepatitis c virus lymphocytes apoptosis tnfα Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a257811a5cff42609afdc72eeaab1f51
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spelling	oai:doaj.org-article:a257811a5cff42609afdc72eeaab1f512021-11-18T08:03:42ZTNFα PRODUCTION AND APOPTOSIS REGULATION IN VIRAL HEPATITIS TYPE C1563-06252313-741X10.15789/1563-0625-2005-4-417-420https://doaj.org/article/a257811a5cff42609afdc72eeaab1f512014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/499https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Chronical course of infection caused by hepatitis C virus is accompanied by increase Fas-positive lymphocytes of peripheral blood. Cultivation of agglutinin-stimulated mononuclear blood cells of patients with chronic hepatitis C revealed inhibition of apoptotic reactions of blood lymphocytes. This fact correlated with decrease in production of TNFα and accelerated synthesis of soluble receptor for this cytokine. We suggest a virus-specific influence on apoptosis regulation of target cells.V. V. NovitskyN. V. RjazantsevaO. B. ZhukovaT. T. RadzivilE. V. BeloborodovaA. P. ZimaI. O. NaslednikovaM. M. LitvakS. L. MikheevSPb RAACIarticlehepatitis c viruslymphocytesapoptosistnfαImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 4, Pp 417-420 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hepatitis c virus lymphocytes apoptosis tnfα Immunologic diseases. Allergy RC581-607
spellingShingle	hepatitis c virus lymphocytes apoptosis tnfα Immunologic diseases. Allergy RC581-607 V. V. Novitsky N. V. Rjazantseva O. B. Zhukova T. T. Radzivil E. V. Beloborodova A. P. Zima I. O. Naslednikova M. M. Litvak S. L. Mikheev TNFα PRODUCTION AND APOPTOSIS REGULATION IN VIRAL HEPATITIS TYPE C
description	Abstract. Chronical course of infection caused by hepatitis C virus is accompanied by increase Fas-positive lymphocytes of peripheral blood. Cultivation of agglutinin-stimulated mononuclear blood cells of patients with chronic hepatitis C revealed inhibition of apoptotic reactions of blood lymphocytes. This fact correlated with decrease in production of TNFα and accelerated synthesis of soluble receptor for this cytokine. We suggest a virus-specific influence on apoptosis regulation of target cells.
format	article
author	V. V. Novitsky N. V. Rjazantseva O. B. Zhukova T. T. Radzivil E. V. Beloborodova A. P. Zima I. O. Naslednikova M. M. Litvak S. L. Mikheev
author_facet	V. V. Novitsky N. V. Rjazantseva O. B. Zhukova T. T. Radzivil E. V. Beloborodova A. P. Zima I. O. Naslednikova M. M. Litvak S. L. Mikheev
author_sort	V. V. Novitsky
title	TNFα PRODUCTION AND APOPTOSIS REGULATION IN VIRAL HEPATITIS TYPE C
title_short	TNFα PRODUCTION AND APOPTOSIS REGULATION IN VIRAL HEPATITIS TYPE C
title_full	TNFα PRODUCTION AND APOPTOSIS REGULATION IN VIRAL HEPATITIS TYPE C
title_fullStr	TNFα PRODUCTION AND APOPTOSIS REGULATION IN VIRAL HEPATITIS TYPE C
title_full_unstemmed	TNFα PRODUCTION AND APOPTOSIS REGULATION IN VIRAL HEPATITIS TYPE C
title_sort	tnfα production and apoptosis regulation in viral hepatitis type c
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/a257811a5cff42609afdc72eeaab1f51
work_keys_str_mv	AT vvnovitsky tnfaproductionandapoptosisregulationinviralhepatitistypec AT nvrjazantseva tnfaproductionandapoptosisregulationinviralhepatitistypec AT obzhukova tnfaproductionandapoptosisregulationinviralhepatitistypec AT ttradzivil tnfaproductionandapoptosisregulationinviralhepatitistypec AT evbeloborodova tnfaproductionandapoptosisregulationinviralhepatitistypec AT apzima tnfaproductionandapoptosisregulationinviralhepatitistypec AT ionaslednikova tnfaproductionandapoptosisregulationinviralhepatitistypec AT mmlitvak tnfaproductionandapoptosisregulationinviralhepatitistypec AT slmikheev tnfaproductionandapoptosisregulationinviralhepatitistypec
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TNFα PRODUCTION AND APOPTOSIS REGULATION IN VIRAL HEPATITIS TYPE C

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