Different Therapeutic Strategies in 2 Young Patients with Advanced ALK-Rearranged Lung Adenocarcinoma: “The Light at the End of the Tunnel”

Malignant pleural effusion represents a prognostic negative factor on survival conferring stage IV disease. The median of survival is 5 months and a 5-year survival of about 3%. We describe the therapeutic success obtained from different strategies in anaplastic lymphoma kinase (ALK) inhibitors in 2...

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Autores principales:	Umberto Caterino, Cristiano Cesaro, Enzo Zamparelli, Flavio Cesaro, Alba Palma, Raffaella Lucci, Pasquale Imitazione, Dino Casazza, Dario Amore
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	lung adenocarcinoma malignant pleural effusion anaplastic lymphoma kinase inhibitor therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a25798b70e3548b9b36e29ee8da2a987
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spelling	oai:doaj.org-article:a25798b70e3548b9b36e29ee8da2a9872021-12-02T12:40:23ZDifferent Therapeutic Strategies in 2 Young Patients with Advanced ALK-Rearranged Lung Adenocarcinoma: “The Light at the End of the Tunnel”1662-657510.1159/000520127https://doaj.org/article/a25798b70e3548b9b36e29ee8da2a9872021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520127https://doaj.org/toc/1662-6575Malignant pleural effusion represents a prognostic negative factor on survival conferring stage IV disease. The median of survival is 5 months and a 5-year survival of about 3%. We describe the therapeutic success obtained from different strategies in anaplastic lymphoma kinase (ALK) inhibitors in 2 young women showing malignant pleural effusion secondary to advanced ALK-rearranged lung adenocarcinoma. This report shows that for patients with EGFR mutations in advanced lung adenocarcinoma-associated malignant pleural effusion, complete response to EGFR TKI inhibitor can be observed mostly if pleural effusion and primary lung adenocarcinoma show the same EGFR mutation status.Umberto CaterinoCristiano CesaroEnzo ZamparelliFlavio CesaroAlba PalmaRaffaella LucciPasquale ImitazioneDino CasazzaDario AmoreKarger Publishersarticlelung adenocarcinomamalignant pleural effusionanaplastic lymphoma kinase inhibitor therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCase Reports in Oncology, Vol 14, Iss 3, Pp 1616-1620 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung adenocarcinoma malignant pleural effusion anaplastic lymphoma kinase inhibitor therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	lung adenocarcinoma malignant pleural effusion anaplastic lymphoma kinase inhibitor therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Umberto Caterino Cristiano Cesaro Enzo Zamparelli Flavio Cesaro Alba Palma Raffaella Lucci Pasquale Imitazione Dino Casazza Dario Amore Different Therapeutic Strategies in 2 Young Patients with Advanced ALK-Rearranged Lung Adenocarcinoma: “The Light at the End of the Tunnel”
description	Malignant pleural effusion represents a prognostic negative factor on survival conferring stage IV disease. The median of survival is 5 months and a 5-year survival of about 3%. We describe the therapeutic success obtained from different strategies in anaplastic lymphoma kinase (ALK) inhibitors in 2 young women showing malignant pleural effusion secondary to advanced ALK-rearranged lung adenocarcinoma. This report shows that for patients with EGFR mutations in advanced lung adenocarcinoma-associated malignant pleural effusion, complete response to EGFR TKI inhibitor can be observed mostly if pleural effusion and primary lung adenocarcinoma show the same EGFR mutation status.
format	article
author	Umberto Caterino Cristiano Cesaro Enzo Zamparelli Flavio Cesaro Alba Palma Raffaella Lucci Pasquale Imitazione Dino Casazza Dario Amore
author_facet	Umberto Caterino Cristiano Cesaro Enzo Zamparelli Flavio Cesaro Alba Palma Raffaella Lucci Pasquale Imitazione Dino Casazza Dario Amore
author_sort	Umberto Caterino
title	Different Therapeutic Strategies in 2 Young Patients with Advanced ALK-Rearranged Lung Adenocarcinoma: “The Light at the End of the Tunnel”
title_short	Different Therapeutic Strategies in 2 Young Patients with Advanced ALK-Rearranged Lung Adenocarcinoma: “The Light at the End of the Tunnel”
title_full	Different Therapeutic Strategies in 2 Young Patients with Advanced ALK-Rearranged Lung Adenocarcinoma: “The Light at the End of the Tunnel”
title_fullStr	Different Therapeutic Strategies in 2 Young Patients with Advanced ALK-Rearranged Lung Adenocarcinoma: “The Light at the End of the Tunnel”
title_full_unstemmed	Different Therapeutic Strategies in 2 Young Patients with Advanced ALK-Rearranged Lung Adenocarcinoma: “The Light at the End of the Tunnel”
title_sort	different therapeutic strategies in 2 young patients with advanced alk-rearranged lung adenocarcinoma: “the light at the end of the tunnel”
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/a25798b70e3548b9b36e29ee8da2a987
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Different Therapeutic Strategies in 2 Young Patients with Advanced ALK-Rearranged Lung Adenocarcinoma: “The Light at the End of the Tunnel”

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