Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score

Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.Met...

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Autores principales:	Mohammad Abumayyaleh, Iván J. Nuñez-Gil, Ibrahim El-Battrawy, Vicente Estrada, Víctor Manuel Becerra-Muñoz, Aitor Uribarri, Inmaculada Fernández-Rozas, Gisela Feltes, Ramón Arroyo-Espliguero, Daniela Trabattoni, Javier López Pais, Martino Pepe, Rodolfo Romero, María Elizabeth Ortega-Armas, Matteo Bianco, Thamar Capel Astrua, Fabrizio D'Ascenzo, Oscar Fabregat-Andres, Andrea Ballester, Francisco Marín, Danilo Buonsenso, Raul Sanchez-Gimenez, Christel Weiß, Cristina Fernandez Perez, Antonio Fernández-Ortiz, Carlos Macaya, Ibrahim Akin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sepsis score COVID-19 SARS-CoV-2 outcome Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a25b194a1b0c404bb0255cf153c10282
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spelling	oai:doaj.org-article:a25b194a1b0c404bb0255cf153c102822021-11-05T16:28:06ZSepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score2296-858X10.3389/fmed.2021.728102https://doaj.org/article/a25b194a1b0c404bb0255cf153c102822021-10-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.728102/fullhttps://doaj.org/toc/2296-858XBackground: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus.Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO2) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1–11.8%); intermediate-risk group (24.8–53.8%); and high-risk-group (58.3–100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO2, decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis.Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.Mohammad AbumayyalehIván J. Nuñez-GilIbrahim El-BattrawyVicente EstradaVíctor Manuel Becerra-MuñozAitor UribarriInmaculada Fernández-RozasGisela FeltesRamón Arroyo-EspligueroDaniela TrabattoniJavier López PaisMartino PepeRodolfo RomeroMaría Elizabeth Ortega-ArmasMatteo BiancoThamar Capel AstruaFabrizio D'AscenzoOscar Fabregat-AndresAndrea BallesterFrancisco MarínDanilo BuonsensoRaul Sanchez-GimenezChristel WeißCristina Fernandez PerezAntonio Fernández-OrtizCarlos MacayaIbrahim AkinFrontiers Media S.A.articlesepsisscoreCOVID-19SARS-CoV-2outcomeMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sepsis score COVID-19 SARS-CoV-2 outcome Medicine (General) R5-920
spellingShingle	sepsis score COVID-19 SARS-CoV-2 outcome Medicine (General) R5-920 Mohammad Abumayyaleh Iván J. Nuñez-Gil Ibrahim El-Battrawy Vicente Estrada Víctor Manuel Becerra-Muñoz Aitor Uribarri Inmaculada Fernández-Rozas Gisela Feltes Ramón Arroyo-Espliguero Daniela Trabattoni Javier López Pais Martino Pepe Rodolfo Romero María Elizabeth Ortega-Armas Matteo Bianco Thamar Capel Astrua Fabrizio D'Ascenzo Oscar Fabregat-Andres Andrea Ballester Francisco Marín Danilo Buonsenso Raul Sanchez-Gimenez Christel Weiß Cristina Fernandez Perez Antonio Fernández-Ortiz Carlos Macaya Ibrahim Akin Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
description	Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus.Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO2) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1–11.8%); intermediate-risk group (24.8–53.8%); and high-risk-group (58.3–100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO2, decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis.Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.
format	article
author	Mohammad Abumayyaleh Iván J. Nuñez-Gil Ibrahim El-Battrawy Vicente Estrada Víctor Manuel Becerra-Muñoz Aitor Uribarri Inmaculada Fernández-Rozas Gisela Feltes Ramón Arroyo-Espliguero Daniela Trabattoni Javier López Pais Martino Pepe Rodolfo Romero María Elizabeth Ortega-Armas Matteo Bianco Thamar Capel Astrua Fabrizio D'Ascenzo Oscar Fabregat-Andres Andrea Ballester Francisco Marín Danilo Buonsenso Raul Sanchez-Gimenez Christel Weiß Cristina Fernandez Perez Antonio Fernández-Ortiz Carlos Macaya Ibrahim Akin
author_facet	Mohammad Abumayyaleh Iván J. Nuñez-Gil Ibrahim El-Battrawy Vicente Estrada Víctor Manuel Becerra-Muñoz Aitor Uribarri Inmaculada Fernández-Rozas Gisela Feltes Ramón Arroyo-Espliguero Daniela Trabattoni Javier López Pais Martino Pepe Rodolfo Romero María Elizabeth Ortega-Armas Matteo Bianco Thamar Capel Astrua Fabrizio D'Ascenzo Oscar Fabregat-Andres Andrea Ballester Francisco Marín Danilo Buonsenso Raul Sanchez-Gimenez Christel Weiß Cristina Fernandez Perez Antonio Fernández-Ortiz Carlos Macaya Ibrahim Akin
author_sort	Mohammad Abumayyaleh
title	Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
title_short	Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
title_full	Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
title_fullStr	Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
title_full_unstemmed	Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
title_sort	sepsis of patients infected by sars-cov-2: real-world experience from the international hope-covid-19-registry and validation of hope sepsis score
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a25b194a1b0c404bb0255cf153c10282
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Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score

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