Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains

Chimeric antigen receptors (CAR) use antibody variable regions to activate anti-tumor immunity. Here the authors show that a mouse IgH/IgL variable region used in a clinical CAR induces host immune responses to possibly reduce therapy efficacy, but an IgH-only CAR T design achieves similar CAR T act...

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Autores principales:	Norris Lam, Nathan D. Trinklein, Benjamin Buelow, George H. Patterson, Namrata Ojha, James N. Kochenderfer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a25f26915c1c45269a9ab2d9dfccb998
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spelling	oai:doaj.org-article:a25f26915c1c45269a9ab2d9dfccb9982021-12-02T15:37:19ZAnti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains10.1038/s41467-019-14119-92041-1723https://doaj.org/article/a25f26915c1c45269a9ab2d9dfccb9982020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14119-9https://doaj.org/toc/2041-1723Chimeric antigen receptors (CAR) use antibody variable regions to activate anti-tumor immunity. Here the authors show that a mouse IgH/IgL variable region used in a clinical CAR induces host immune responses to possibly reduce therapy efficacy, but an IgH-only CAR T design achieves similar CAR T activity but is potentially less immunogenic.Norris LamNathan D. TrinkleinBenjamin BuelowGeorge H. PattersonNamrata OjhaJames N. KochenderferNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Norris Lam Nathan D. Trinklein Benjamin Buelow George H. Patterson Namrata Ojha James N. Kochenderfer Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
description	Chimeric antigen receptors (CAR) use antibody variable regions to activate anti-tumor immunity. Here the authors show that a mouse IgH/IgL variable region used in a clinical CAR induces host immune responses to possibly reduce therapy efficacy, but an IgH-only CAR T design achieves similar CAR T activity but is potentially less immunogenic.
format	article
author	Norris Lam Nathan D. Trinklein Benjamin Buelow George H. Patterson Namrata Ojha James N. Kochenderfer
author_facet	Norris Lam Nathan D. Trinklein Benjamin Buelow George H. Patterson Namrata Ojha James N. Kochenderfer
author_sort	Norris Lam
title	Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
title_short	Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
title_full	Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
title_fullStr	Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
title_full_unstemmed	Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
title_sort	anti-bcma chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a25f26915c1c45269a9ab2d9dfccb998
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Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains

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