Relation of high neuroticism with increased methylation of the BDNF gene

Toshinori Shirata,1 Akihito Suzuki,1 Yoshihiko Matsumoto,1 Nana Takahashi,1 Keisuke Noto,1 Kaoru Goto,2 Koichi Otani1 1Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan; 2Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata, Japan...

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Autores principales:	Shirata T, Suzuki A, Matsumoto Y, Takahashi N, Noto K, Goto K, Otani K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	BDNF depression epigenetics methylation neuroticism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a2602c1bbe4e4f02b706f11825267ed1
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spelling	oai:doaj.org-article:a2602c1bbe4e4f02b706f11825267ed12021-12-02T07:54:01ZRelation of high neuroticism with increased methylation of the BDNF gene1178-2021https://doaj.org/article/a2602c1bbe4e4f02b706f11825267ed12018-07-01T00:00:00Zhttps://www.dovepress.com/relation-of-high-neuroticism-with-increased-methylation-of-the-bdnf-ge-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Toshinori Shirata,1 Akihito Suzuki,1 Yoshihiko Matsumoto,1 Nana Takahashi,1 Keisuke Noto,1 Kaoru Goto,2 Koichi Otani1 1Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan; 2Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata, Japan Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has an important function in neuroplasticity and neuronal development. It is suggested that increased methylation of the BDNF gene resulting in decreased BDNF activity is associated with depression. Meanwhile, neuroticism is a well-known risk factor for developing depression. In the present study, the relationship between methylation of the BDNF gene and personality traits including neuroticism was examined. Subjects and methods: The subjects were 98 healthy Japanese. Methylation levels of the BDNF gene were determined by the bisulfite-pyrosequencing method. Personality traits including neuroticism were assessed by the NEO Personality Inventory-Revised. Results: There was a positive correlation between neuroticism scores and methylation levels of the BDNF gene. The subjects with higher neuroticism scores had higher levels of BDNF gene methylation compared with those with lower neuroticism scores. Meanwhile, other personality traits were not associated with BDNF gene methylation. Conclusion: The present study suggests that high neuroticism is related to increased methylation of the BDNF gene. Keywords: BDNF, depression, epigenetics, methylation, neuroticismShirata TSuzuki AMatsumoto YTakahashi NNoto KGoto KOtani KDove Medical PressarticleBDNFdepressionepigeneticsmethylationneuroticismNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1787-1793 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	BDNF depression epigenetics methylation neuroticism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	BDNF depression epigenetics methylation neuroticism Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Shirata T Suzuki A Matsumoto Y Takahashi N Noto K Goto K Otani K Relation of high neuroticism with increased methylation of the BDNF gene
description	Toshinori Shirata,1 Akihito Suzuki,1 Yoshihiko Matsumoto,1 Nana Takahashi,1 Keisuke Noto,1 Kaoru Goto,2 Koichi Otani1 1Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan; 2Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata, Japan Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has an important function in neuroplasticity and neuronal development. It is suggested that increased methylation of the BDNF gene resulting in decreased BDNF activity is associated with depression. Meanwhile, neuroticism is a well-known risk factor for developing depression. In the present study, the relationship between methylation of the BDNF gene and personality traits including neuroticism was examined. Subjects and methods: The subjects were 98 healthy Japanese. Methylation levels of the BDNF gene were determined by the bisulfite-pyrosequencing method. Personality traits including neuroticism were assessed by the NEO Personality Inventory-Revised. Results: There was a positive correlation between neuroticism scores and methylation levels of the BDNF gene. The subjects with higher neuroticism scores had higher levels of BDNF gene methylation compared with those with lower neuroticism scores. Meanwhile, other personality traits were not associated with BDNF gene methylation. Conclusion: The present study suggests that high neuroticism is related to increased methylation of the BDNF gene. Keywords: BDNF, depression, epigenetics, methylation, neuroticism
format	article
author	Shirata T Suzuki A Matsumoto Y Takahashi N Noto K Goto K Otani K
author_facet	Shirata T Suzuki A Matsumoto Y Takahashi N Noto K Goto K Otani K
author_sort	Shirata T
title	Relation of high neuroticism with increased methylation of the BDNF gene
title_short	Relation of high neuroticism with increased methylation of the BDNF gene
title_full	Relation of high neuroticism with increased methylation of the BDNF gene
title_fullStr	Relation of high neuroticism with increased methylation of the BDNF gene
title_full_unstemmed	Relation of high neuroticism with increased methylation of the BDNF gene
title_sort	relation of high neuroticism with increased methylation of the bdnf gene
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/a2602c1bbe4e4f02b706f11825267ed1
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Relation of high neuroticism with increased methylation of the BDNF gene

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