Structure of the poly-C9 component of the complement membrane attack complex
The membrane attack complex is a heteromeric assembly of complement proteins where multiple copies of C9 are recruited by the C5b678 complex to form lytic pores in pathogen membranes. Here the authors present the structure of a soluble pore-like form of the C9 component that reveals details of the o...
Guardado en:
Autores principales: | Natalya V. Dudkina, Bradley A. Spicer, Cyril F. Reboul, Paul J. Conroy, Natalya Lukoyanova, Hans Elmlund, Ruby H. P. Law, Susan M. Ekkel, Stephanie C. Kondos, Robert J. A. Goode, Georg Ramm, James C. Whisstock, Helen R. Saibil, Michelle A. Dunstone |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2016
|
Materias: | |
Acceso en línea: | https://doaj.org/article/a2649e95879f4957bec6ff1711385015 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The first transmembrane region of complement component-9 acts as a brake on its self-assembly
por: Bradley A. Spicer, et al.
Publicado: (2018) -
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
por: Siew Siew Pang, et al.
Publicado: (2019) -
Structural basis of complement membrane attack complex formation
por: Marina Serna, et al.
Publicado: (2016) -
The membrane attack complex as an indicator of complement hyperactivation in type 2 diabetes mellitus
por: Elina Alexandrovna Arakelova, et al.
Publicado: (2011) -
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers
por: Anaïs Menny, et al.
Publicado: (2018)