Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1

Abstract Context affects the salience and visibility of image elements in visual scenes. Collinear flankers can enhance or decrease the perceptual and neuronal sensitivity to flanked stimuli. These effects are mediated through lateral interactions between neurons in the primary visual cortex (area V...

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Autores principales:	Jose L. Herrero, Alexander Thiele
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a2666bd59dc7420093cd2182e743f20e
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spelling	oai:doaj.org-article:a2666bd59dc7420093cd2182e743f20e2021-12-02T15:51:15ZEffects of muscarinic and nicotinic receptors on contextual modulation in macaque area V110.1038/s41598-021-88044-72045-2322https://doaj.org/article/a2666bd59dc7420093cd2182e743f20e2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88044-7https://doaj.org/toc/2045-2322Abstract Context affects the salience and visibility of image elements in visual scenes. Collinear flankers can enhance or decrease the perceptual and neuronal sensitivity to flanked stimuli. These effects are mediated through lateral interactions between neurons in the primary visual cortex (area V1), in conjunction with feedback from higher visual areas. The strength of lateral interactions is affected by cholinergic neuromodulation. Blockade of muscarinic receptors should increase the strength of lateral intracortical interactions, while nicotinic blockade should reduce thalamocortical feed-forward drive. Here we test this proposal through local iontophoretic application of the muscarinic receptor antagonist scopolamine and the nicotinic receptor antagonist mecamylamine, while recording single cells in parafoveal representations in awake fixating macaque V1. Collinear flankers generally reduced neuronal contrast sensitivity. Muscarinic and nicotinic receptor blockade equally reduced neuronal contrast sensitivity. Contrary to our hypothesis, flanker interactions were not systematically affected by either receptor blockade.Jose L. HerreroAlexander ThieleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jose L. Herrero Alexander Thiele Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
description	Abstract Context affects the salience and visibility of image elements in visual scenes. Collinear flankers can enhance or decrease the perceptual and neuronal sensitivity to flanked stimuli. These effects are mediated through lateral interactions between neurons in the primary visual cortex (area V1), in conjunction with feedback from higher visual areas. The strength of lateral interactions is affected by cholinergic neuromodulation. Blockade of muscarinic receptors should increase the strength of lateral intracortical interactions, while nicotinic blockade should reduce thalamocortical feed-forward drive. Here we test this proposal through local iontophoretic application of the muscarinic receptor antagonist scopolamine and the nicotinic receptor antagonist mecamylamine, while recording single cells in parafoveal representations in awake fixating macaque V1. Collinear flankers generally reduced neuronal contrast sensitivity. Muscarinic and nicotinic receptor blockade equally reduced neuronal contrast sensitivity. Contrary to our hypothesis, flanker interactions were not systematically affected by either receptor blockade.
format	article
author	Jose L. Herrero Alexander Thiele
author_facet	Jose L. Herrero Alexander Thiele
author_sort	Jose L. Herrero
title	Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
title_short	Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
title_full	Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
title_fullStr	Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
title_full_unstemmed	Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
title_sort	effects of muscarinic and nicotinic receptors on contextual modulation in macaque area v1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2666bd59dc7420093cd2182e743f20e
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Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1

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