Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

Zheng Zhao,1,3 Maobin Xie,2 Yi Li,2 Aizheng Chen,4 Gang Li,5 Jing Zhang,2 Huawen Hu,2 Xinyu Wang,1,3 Shipu Li1,31State Key Lab of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, People’s Republic of China; 2Institute of Textiles and Clothi...

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Autores principales:	Zhao Z, Xie M, Li Y, Chen A, Li G, Zhang J, Hu H, Wang X, Li S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a268858660b840608ca764a75d6516b3
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spelling	oai:doaj.org-article:a268858660b840608ca764a75d6516b32021-12-02T05:03:09ZFormation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO21178-2013https://doaj.org/article/a268858660b840608ca764a75d6516b32015-04-01T00:00:00Zhttp://www.dovepress.com/formation-of-curcumin-nanoparticles-via-solution-enhanced-dispersion-b-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zheng Zhao,1,3 Maobin Xie,2 Yi Li,2 Aizheng Chen,4 Gang Li,5 Jing Zhang,2 Huawen Hu,2 Xinyu Wang,1,3 Shipu Li1,31State Key Lab of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, People’s Republic of China; 2Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong; 3Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan, People’s Republic of China; 4College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of China; 5National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, People’s Republic of ChinaAbstract: In order to enhance the bioavailability of poorly water-soluble curcumin, solution-enhanced dispersion by supercritical carbon dioxide (CO2) (SEDS) was employed to prepare curcumin nanoparticles for the first time. A 24 full factorial experiment was designed to determine optimal processing parameters and their influence on the size of the curcumin nanoparticles. Particle size was demonstrated to increase with increased temperature or flow rate of the solution, or with decreased precipitation pressure, under processing conditions with different parameters considered. The single effect of the concentration of the solution on particle size was not significant. Curcumin nanoparticles with a spherical shape and the smallest mean particle size of 325 nm were obtained when the following optimal processing conditions were adopted: P =20 MPa, T =35°C, flow rate of solution =0.5 mL.min-1, concentration of solution =0.5%. Fourier transform infrared (FTIR) spectroscopy measurement revealed that the chemical composition of curcumin basically remained unchanged. Nevertheless, X-ray powder diffraction (XRPD) and thermal analysis indicated that the crystalline state of the original curcumin decreased after the SEDS process. The solubility and dissolution rate of the curcumin nanoparticles were found to be higher than that of the original curcumin powder (approximately 1.4 µg/mL vs 0.2 µg/mL in 180 minutes). This study revealed that supercritical CO2 technologies had a great potential in fabricating nanoparticles and improving the bioavailability of poorly water-soluble drugs.Keywords: curcumin, crystalline sate, dissolution rate, solubilityZhao ZXie MLi YChen ALi GZhang JHu HWang XLi SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3171-3181 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhao Z Xie M Li Y Chen A Li G Zhang J Hu H Wang X Li S Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2
description	Zheng Zhao,1,3 Maobin Xie,2 Yi Li,2 Aizheng Chen,4 Gang Li,5 Jing Zhang,2 Huawen Hu,2 Xinyu Wang,1,3 Shipu Li1,31State Key Lab of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, People’s Republic of China; 2Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong; 3Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan, People’s Republic of China; 4College of Chemical Engineering, Huaqiao University, Xiamen, People’s Republic of China; 5National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, People’s Republic of ChinaAbstract: In order to enhance the bioavailability of poorly water-soluble curcumin, solution-enhanced dispersion by supercritical carbon dioxide (CO2) (SEDS) was employed to prepare curcumin nanoparticles for the first time. A 24 full factorial experiment was designed to determine optimal processing parameters and their influence on the size of the curcumin nanoparticles. Particle size was demonstrated to increase with increased temperature or flow rate of the solution, or with decreased precipitation pressure, under processing conditions with different parameters considered. The single effect of the concentration of the solution on particle size was not significant. Curcumin nanoparticles with a spherical shape and the smallest mean particle size of 325 nm were obtained when the following optimal processing conditions were adopted: P =20 MPa, T =35°C, flow rate of solution =0.5 mL.min-1, concentration of solution =0.5%. Fourier transform infrared (FTIR) spectroscopy measurement revealed that the chemical composition of curcumin basically remained unchanged. Nevertheless, X-ray powder diffraction (XRPD) and thermal analysis indicated that the crystalline state of the original curcumin decreased after the SEDS process. The solubility and dissolution rate of the curcumin nanoparticles were found to be higher than that of the original curcumin powder (approximately 1.4 µg/mL vs 0.2 µg/mL in 180 minutes). This study revealed that supercritical CO2 technologies had a great potential in fabricating nanoparticles and improving the bioavailability of poorly water-soluble drugs.Keywords: curcumin, crystalline sate, dissolution rate, solubility
format	article
author	Zhao Z Xie M Li Y Chen A Li G Zhang J Hu H Wang X Li S
author_facet	Zhao Z Xie M Li Y Chen A Li G Zhang J Hu H Wang X Li S
author_sort	Zhao Z
title	Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2
title_short	Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2
title_full	Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2
title_fullStr	Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2
title_full_unstemmed	Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2
title_sort	formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical co2
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/a268858660b840608ca764a75d6516b3
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_version_	1718400727101997056

Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2

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