Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study

Abstract Brain-computer interface-assisted motor imagery (MI-BCI) or transcranial direct current stimulation (tDCS) has been used in stroke rehabilitation, though their combinatory effect is unknown. We investigated brain plasticity following a combined MI-BCI and tDCS intervention in chronic subcor...

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Autores principales:	Xin Hong, Zhong Kang Lu, Irvin Teh, Fatima Ali Nasrallah, Wei Peng Teo, Kai Keng Ang, Kok Soon Phua, Cuntai Guan, Effie Chew, Kai-Hsiang Chuang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a268aee792a64227bfcea1f2dee4e8cb
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spelling	oai:doaj.org-article:a268aee792a64227bfcea1f2dee4e8cb2021-12-02T16:06:30ZBrain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study10.1038/s41598-017-08928-52045-2322https://doaj.org/article/a268aee792a64227bfcea1f2dee4e8cb2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08928-5https://doaj.org/toc/2045-2322Abstract Brain-computer interface-assisted motor imagery (MI-BCI) or transcranial direct current stimulation (tDCS) has been used in stroke rehabilitation, though their combinatory effect is unknown. We investigated brain plasticity following a combined MI-BCI and tDCS intervention in chronic subcortical stroke patients with unilateral upper limb disability. Nineteen patients were randomized into tDCS and sham-tDCS groups. Diffusion and perfusion MRI, and transcranial magnetic stimulation were used to study structural connectivity, cerebral blood flow (CBF), and corticospinal excitability, respectively, before and 4 weeks after the 2-week intervention. After quality control, thirteen subjects were included in the CBF analysis. Eleven healthy controls underwent 2 sessions of MRI for reproducibility study. Whereas motor performance showed comparable improvement, long-lasting neuroplasticity can only be detected in the tDCS group, where white matter integrity in the ipsilesional corticospinal tract and bilateral corpus callosum was increased but sensorimotor CBF was decreased, particularly in the ipsilesional side. CBF change in the bilateral parietal cortices also correlated with motor function improvement, consistent with the increased white matter integrity in the corpus callosum connecting these regions, suggesting an involvement of interhemispheric interaction. The preliminary results indicate that tDCS may facilitate neuroplasticity and suggest the potential for refining rehabilitation strategies for stroke patients.Xin HongZhong Kang LuIrvin TehFatima Ali NasrallahWei Peng TeoKai Keng AngKok Soon PhuaCuntai GuanEffie ChewKai-Hsiang ChuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Hong Zhong Kang Lu Irvin Teh Fatima Ali Nasrallah Wei Peng Teo Kai Keng Ang Kok Soon Phua Cuntai Guan Effie Chew Kai-Hsiang Chuang Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study
description	Abstract Brain-computer interface-assisted motor imagery (MI-BCI) or transcranial direct current stimulation (tDCS) has been used in stroke rehabilitation, though their combinatory effect is unknown. We investigated brain plasticity following a combined MI-BCI and tDCS intervention in chronic subcortical stroke patients with unilateral upper limb disability. Nineteen patients were randomized into tDCS and sham-tDCS groups. Diffusion and perfusion MRI, and transcranial magnetic stimulation were used to study structural connectivity, cerebral blood flow (CBF), and corticospinal excitability, respectively, before and 4 weeks after the 2-week intervention. After quality control, thirteen subjects were included in the CBF analysis. Eleven healthy controls underwent 2 sessions of MRI for reproducibility study. Whereas motor performance showed comparable improvement, long-lasting neuroplasticity can only be detected in the tDCS group, where white matter integrity in the ipsilesional corticospinal tract and bilateral corpus callosum was increased but sensorimotor CBF was decreased, particularly in the ipsilesional side. CBF change in the bilateral parietal cortices also correlated with motor function improvement, consistent with the increased white matter integrity in the corpus callosum connecting these regions, suggesting an involvement of interhemispheric interaction. The preliminary results indicate that tDCS may facilitate neuroplasticity and suggest the potential for refining rehabilitation strategies for stroke patients.
format	article
author	Xin Hong Zhong Kang Lu Irvin Teh Fatima Ali Nasrallah Wei Peng Teo Kai Keng Ang Kok Soon Phua Cuntai Guan Effie Chew Kai-Hsiang Chuang
author_facet	Xin Hong Zhong Kang Lu Irvin Teh Fatima Ali Nasrallah Wei Peng Teo Kai Keng Ang Kok Soon Phua Cuntai Guan Effie Chew Kai-Hsiang Chuang
author_sort	Xin Hong
title	Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study
title_short	Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study
title_full	Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study
title_fullStr	Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study
title_full_unstemmed	Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study
title_sort	brain plasticity following mi-bci training combined with tdcs in a randomized trial in chronic subcortical stroke subjects: a preliminary study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a268aee792a64227bfcea1f2dee4e8cb
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Brain plasticity following MI-BCI training combined with tDCS in a randomized trial in chronic subcortical stroke subjects: a preliminary study

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