FBW7 couples structural integrity with functional output of primary cilia

Petsouki et al. dissect the importance of FBW7-mediated regulation of NDE1 and TALPID3 in mesenchymal stem cells (MSCs). They find that by modulating the abundance of negative (NDE1) and positive (TALPID3) cilia regulators, FBW7 contributes to both the assembly and signaling functions of primary cil...

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Autores principales:	Eleni Petsouki, Vasileios Gerakopoulos, Nicholas Szeto, Wenhan Chang, Mary Beth Humphrey, Leonidas Tsiokas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a269982ff2f24864a1170fac0d97006f
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spelling	oai:doaj.org-article:a269982ff2f24864a1170fac0d97006f2021-12-02T15:15:34ZFBW7 couples structural integrity with functional output of primary cilia10.1038/s42003-021-02504-42399-3642https://doaj.org/article/a269982ff2f24864a1170fac0d97006f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02504-4https://doaj.org/toc/2399-3642Petsouki et al. dissect the importance of FBW7-mediated regulation of NDE1 and TALPID3 in mesenchymal stem cells (MSCs). They find that by modulating the abundance of negative (NDE1) and positive (TALPID3) cilia regulators, FBW7 contributes to both the assembly and signaling functions of primary cilia that are necessary for osteoblast differentiation.Eleni PetsoukiVasileios GerakopoulosNicholas SzetoWenhan ChangMary Beth HumphreyLeonidas TsiokasNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Eleni Petsouki Vasileios Gerakopoulos Nicholas Szeto Wenhan Chang Mary Beth Humphrey Leonidas Tsiokas FBW7 couples structural integrity with functional output of primary cilia
description	Petsouki et al. dissect the importance of FBW7-mediated regulation of NDE1 and TALPID3 in mesenchymal stem cells (MSCs). They find that by modulating the abundance of negative (NDE1) and positive (TALPID3) cilia regulators, FBW7 contributes to both the assembly and signaling functions of primary cilia that are necessary for osteoblast differentiation.
format	article
author	Eleni Petsouki Vasileios Gerakopoulos Nicholas Szeto Wenhan Chang Mary Beth Humphrey Leonidas Tsiokas
author_facet	Eleni Petsouki Vasileios Gerakopoulos Nicholas Szeto Wenhan Chang Mary Beth Humphrey Leonidas Tsiokas
author_sort	Eleni Petsouki
title	FBW7 couples structural integrity with functional output of primary cilia
title_short	FBW7 couples structural integrity with functional output of primary cilia
title_full	FBW7 couples structural integrity with functional output of primary cilia
title_fullStr	FBW7 couples structural integrity with functional output of primary cilia
title_full_unstemmed	FBW7 couples structural integrity with functional output of primary cilia
title_sort	fbw7 couples structural integrity with functional output of primary cilia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a269982ff2f24864a1170fac0d97006f
work_keys_str_mv	AT elenipetsouki fbw7couplesstructuralintegritywithfunctionaloutputofprimarycilia AT vasileiosgerakopoulos fbw7couplesstructuralintegritywithfunctionaloutputofprimarycilia AT nicholasszeto fbw7couplesstructuralintegritywithfunctionaloutputofprimarycilia AT wenhanchang fbw7couplesstructuralintegritywithfunctionaloutputofprimarycilia AT marybethhumphrey fbw7couplesstructuralintegritywithfunctionaloutputofprimarycilia AT leonidastsiokas fbw7couplesstructuralintegritywithfunctionaloutputofprimarycilia
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FBW7 couples structural integrity with functional output of primary cilia

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