Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb

Abstract Age-related decline in olfactory function affects the quality of life in elderly people and also potentially represents an early clinical symptom of neurodegenerative disorder. Olfactory bulb (OB) plays a central role in olfactory information transmitting and signal processing. The mechanis...

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Autores principales:	Ming Wang, Wei Liu, Jian Jiao, Jingyun Li, Chengshuo Wang, Luo Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a26c34ceefe6444e81c809ab0a3dc05e
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spelling	oai:doaj.org-article:a26c34ceefe6444e81c809ab0a3dc05e2021-12-02T15:05:14ZExpression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb10.1038/s41598-017-02329-42045-2322https://doaj.org/article/a26c34ceefe6444e81c809ab0a3dc05e2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02329-4https://doaj.org/toc/2045-2322Abstract Age-related decline in olfactory function affects the quality of life in elderly people and also potentially represents an early clinical symptom of neurodegenerative disorder. Olfactory bulb (OB) plays a central role in olfactory information transmitting and signal processing. The mechanisms underlying this impairment remain unclear. In the current study, microarray was used to investigate differentially expressed protein coding genes (PCGs) and long non-coding RNAs (lncRNAs) in OBs from three groups of mice of different ages (2 months-old young adults, 6 months-old mature adults and 20 months-old aged adults), for their potential roles in olfactory impairment. Gene Ontology and pathway analysis results showed that the differentially expressed PCGs in the OBs from aged mice were mainly associated with signal transduction, regulation of gene expression and cellular microenvironment. Similarly, gene set enrichment analysis identified two differentially and inversely expressed lncRNAs (NONMMUT004524 and NONMMUT000384), both of which were significantly associated with neuroactive ligand-receptor interaction pathway in the OBs of aged mice. These findings suggest that a decline of olfactory function in aged mice may be linked to differential expression of specific lncRNAs and their potentially adverse effects on the neuroactive ligand-receptor interaction pathway in the OB.Ming WangWei LiuJian JiaoJingyun LiChengshuo WangLuo ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ming Wang Wei Liu Jian Jiao Jingyun Li Chengshuo Wang Luo Zhang Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb
description	Abstract Age-related decline in olfactory function affects the quality of life in elderly people and also potentially represents an early clinical symptom of neurodegenerative disorder. Olfactory bulb (OB) plays a central role in olfactory information transmitting and signal processing. The mechanisms underlying this impairment remain unclear. In the current study, microarray was used to investigate differentially expressed protein coding genes (PCGs) and long non-coding RNAs (lncRNAs) in OBs from three groups of mice of different ages (2 months-old young adults, 6 months-old mature adults and 20 months-old aged adults), for their potential roles in olfactory impairment. Gene Ontology and pathway analysis results showed that the differentially expressed PCGs in the OBs from aged mice were mainly associated with signal transduction, regulation of gene expression and cellular microenvironment. Similarly, gene set enrichment analysis identified two differentially and inversely expressed lncRNAs (NONMMUT004524 and NONMMUT000384), both of which were significantly associated with neuroactive ligand-receptor interaction pathway in the OBs of aged mice. These findings suggest that a decline of olfactory function in aged mice may be linked to differential expression of specific lncRNAs and their potentially adverse effects on the neuroactive ligand-receptor interaction pathway in the OB.
format	article
author	Ming Wang Wei Liu Jian Jiao Jingyun Li Chengshuo Wang Luo Zhang
author_facet	Ming Wang Wei Liu Jian Jiao Jingyun Li Chengshuo Wang Luo Zhang
author_sort	Ming Wang
title	Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb
title_short	Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb
title_full	Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb
title_fullStr	Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb
title_full_unstemmed	Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb
title_sort	expression profiling of mrnas and long non-coding rnas in aged mouse olfactory bulb
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a26c34ceefe6444e81c809ab0a3dc05e
work_keys_str_mv	AT mingwang expressionprofilingofmrnasandlongnoncodingrnasinagedmouseolfactorybulb AT weiliu expressionprofilingofmrnasandlongnoncodingrnasinagedmouseolfactorybulb AT jianjiao expressionprofilingofmrnasandlongnoncodingrnasinagedmouseolfactorybulb AT jingyunli expressionprofilingofmrnasandlongnoncodingrnasinagedmouseolfactorybulb AT chengshuowang expressionprofilingofmrnasandlongnoncodingrnasinagedmouseolfactorybulb AT luozhang expressionprofilingofmrnasandlongnoncodingrnasinagedmouseolfactorybulb
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Expression Profiling of mRNAs and Long Non-Coding RNAs in Aged Mouse Olfactory Bulb

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