Structural insights into SorCS2–Nerve Growth Factor complex formation

The Sortilin-related CNS-expressed receptor 2 (SorCS2)–proneurotrophin signaling system regulates neuronal plasticity and its dysfunction is linked to schizophrenia. Here the authors present the structures of the SorCS2 ectodomain alone and in complex with Nerve Growth Factor, which provides insight...

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Autores principales:	Nadia Leloup, Lucas M. P. Chataigner, Bert J. C. Janssen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a272131e31ee4e99a1f0ca5d3e9dd5cb
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spelling	oai:doaj.org-article:a272131e31ee4e99a1f0ca5d3e9dd5cb2021-12-02T16:49:21ZStructural insights into SorCS2–Nerve Growth Factor complex formation10.1038/s41467-018-05405-z2041-1723https://doaj.org/article/a272131e31ee4e99a1f0ca5d3e9dd5cb2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05405-zhttps://doaj.org/toc/2041-1723The Sortilin-related CNS-expressed receptor 2 (SorCS2)–proneurotrophin signaling system regulates neuronal plasticity and its dysfunction is linked to schizophrenia. Here the authors present the structures of the SorCS2 ectodomain alone and in complex with Nerve Growth Factor, which provides insights into SorCS2 ligand binding and signaling.Nadia LeloupLucas M. P. ChataignerBert J. C. JanssenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nadia Leloup Lucas M. P. Chataigner Bert J. C. Janssen Structural insights into SorCS2–Nerve Growth Factor complex formation
description	The Sortilin-related CNS-expressed receptor 2 (SorCS2)–proneurotrophin signaling system regulates neuronal plasticity and its dysfunction is linked to schizophrenia. Here the authors present the structures of the SorCS2 ectodomain alone and in complex with Nerve Growth Factor, which provides insights into SorCS2 ligand binding and signaling.
format	article
author	Nadia Leloup Lucas M. P. Chataigner Bert J. C. Janssen
author_facet	Nadia Leloup Lucas M. P. Chataigner Bert J. C. Janssen
author_sort	Nadia Leloup
title	Structural insights into SorCS2–Nerve Growth Factor complex formation
title_short	Structural insights into SorCS2–Nerve Growth Factor complex formation
title_full	Structural insights into SorCS2–Nerve Growth Factor complex formation
title_fullStr	Structural insights into SorCS2–Nerve Growth Factor complex formation
title_full_unstemmed	Structural insights into SorCS2–Nerve Growth Factor complex formation
title_sort	structural insights into sorcs2–nerve growth factor complex formation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a272131e31ee4e99a1f0ca5d3e9dd5cb
work_keys_str_mv	AT nadialeloup structuralinsightsintosorcs2nervegrowthfactorcomplexformation AT lucasmpchataigner structuralinsightsintosorcs2nervegrowthfactorcomplexformation AT bertjcjanssen structuralinsightsintosorcs2nervegrowthfactorcomplexformation
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Structural insights into SorCS2–Nerve Growth Factor complex formation

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