Structural insights into SorCS2–Nerve Growth Factor complex formation

The Sortilin-related CNS-expressed receptor 2 (SorCS2)–proneurotrophin signaling system regulates neuronal plasticity and its dysfunction is linked to schizophrenia. Here the authors present the structures of the SorCS2 ectodomain alone and in complex with Nerve Growth Factor, which provides insight...

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Autores principales: Nadia Leloup, Lucas M. P. Chataigner, Bert J. C. Janssen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/a272131e31ee4e99a1f0ca5d3e9dd5cb
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