Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering

ABSTRACT During replication of herpesviruses, capsids escape from the nucleus into the cytoplasm by budding at the inner nuclear membrane. This unusual process is mediated by the viral nuclear egress complex (NEC) that deforms the membrane around the capsid by oligomerizing into a hexagonal, membran...

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Bibliographic Details

Main Authors:	Michael K. Thorsen, Alex Lai, Michelle W. Lee, David P. Hoogerheide, Gerard C. L. Wong, Jack H. Freed, Ekaterina E. Heldwein
Format:	article
Language:	EN
Published:	American Society for Microbiology 2021
Subjects:	HSV-1 nuclear egress membrane interactions membrane budding membrane curvature electron spin resonance Microbiology QR1-502
Online Access:	https://doaj.org/article/a2728f92d10644fab661b50a6946efa7
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