An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

The Asian lineage of Zika virus (ZIKV) has acquired a mutation in NS1 that enhances mosquito infection. Here, Xia et al. show that the same mutation interferes with interferon production through interaction with TBK1 and affects ZIKV replication in mice.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hongjie Xia, Huanle Luo, Chao Shan, Antonio E. Muruato, Bruno T. D. Nunes, Daniele B. A. Medeiros, Jing Zou, Xuping Xie, Maria Isabel Giraldo, Pedro F. C. Vasconcelos, Scott C. Weaver, Tian Wang, Ricardo Rajsbaum, Pei-Yong Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a273eacb2a3240279d0531f686d0666c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a273eacb2a3240279d0531f686d0666c
record_format	dspace
spelling	oai:doaj.org-article:a273eacb2a3240279d0531f686d0666c2021-12-02T15:33:42ZAn evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction10.1038/s41467-017-02816-22041-1723https://doaj.org/article/a273eacb2a3240279d0531f686d0666c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02816-2https://doaj.org/toc/2041-1723The Asian lineage of Zika virus (ZIKV) has acquired a mutation in NS1 that enhances mosquito infection. Here, Xia et al. show that the same mutation interferes with interferon production through interaction with TBK1 and affects ZIKV replication in mice.Hongjie XiaHuanle LuoChao ShanAntonio E. MuruatoBruno T. D. NunesDaniele B. A. MedeirosJing ZouXuping XieMaria Isabel GiraldoPedro F. C. VasconcelosScott C. WeaverTian WangRicardo RajsbaumPei-Yong ShiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongjie Xia Huanle Luo Chao Shan Antonio E. Muruato Bruno T. D. Nunes Daniele B. A. Medeiros Jing Zou Xuping Xie Maria Isabel Giraldo Pedro F. C. Vasconcelos Scott C. Weaver Tian Wang Ricardo Rajsbaum Pei-Yong Shi An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction
description	The Asian lineage of Zika virus (ZIKV) has acquired a mutation in NS1 that enhances mosquito infection. Here, Xia et al. show that the same mutation interferes with interferon production through interaction with TBK1 and affects ZIKV replication in mice.
format	article
author	Hongjie Xia Huanle Luo Chao Shan Antonio E. Muruato Bruno T. D. Nunes Daniele B. A. Medeiros Jing Zou Xuping Xie Maria Isabel Giraldo Pedro F. C. Vasconcelos Scott C. Weaver Tian Wang Ricardo Rajsbaum Pei-Yong Shi
author_facet	Hongjie Xia Huanle Luo Chao Shan Antonio E. Muruato Bruno T. D. Nunes Daniele B. A. Medeiros Jing Zou Xuping Xie Maria Isabel Giraldo Pedro F. C. Vasconcelos Scott C. Weaver Tian Wang Ricardo Rajsbaum Pei-Yong Shi
author_sort	Hongjie Xia
title	An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction
title_short	An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction
title_full	An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction
title_fullStr	An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction
title_full_unstemmed	An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction
title_sort	evolutionary ns1 mutation enhances zika virus evasion of host interferon induction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a273eacb2a3240279d0531f686d0666c
work_keys_str_mv	AT hongjiexia anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT huanleluo anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT chaoshan anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT antonioemuruato anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT brunotdnunes anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT danielebamedeiros anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT jingzou anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT xupingxie anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT mariaisabelgiraldo anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT pedrofcvasconcelos anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT scottcweaver anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT tianwang anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT ricardorajsbaum anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT peiyongshi anevolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT hongjiexia evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT huanleluo evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT chaoshan evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT antonioemuruato evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT brunotdnunes evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT danielebamedeiros evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT jingzou evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT xupingxie evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT mariaisabelgiraldo evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT pedrofcvasconcelos evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT scottcweaver evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT tianwang evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT ricardorajsbaum evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction AT peiyongshi evolutionaryns1mutationenhanceszikavirusevasionofhostinterferoninduction
_version_	1718387041379549184

An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction

Ejemplares similares