Histone deacetylase 10 structure and molecular function as a polyamine deacetylase

Polyamines bind to nucleic acids and their function is regulated by reversible acetylation. Here, the authors show that histone deacetylase 10 is a polyamine deacetylase and present its crystal structure with a bound polyamine transition state analogue inhibitor.

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Autores principales:	Yang Hai, Stephen A. Shinsky, Nicholas J. Porter, David W. Christianson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a275abbed63b43529d75e158a00c61cf
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spelling	oai:doaj.org-article:a275abbed63b43529d75e158a00c61cf2021-12-02T17:06:25ZHistone deacetylase 10 structure and molecular function as a polyamine deacetylase10.1038/ncomms153682041-1723https://doaj.org/article/a275abbed63b43529d75e158a00c61cf2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15368https://doaj.org/toc/2041-1723Polyamines bind to nucleic acids and their function is regulated by reversible acetylation. Here, the authors show that histone deacetylase 10 is a polyamine deacetylase and present its crystal structure with a bound polyamine transition state analogue inhibitor.Yang HaiStephen A. ShinskyNicholas J. PorterDavid W. ChristiansonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Hai Stephen A. Shinsky Nicholas J. Porter David W. Christianson Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
description	Polyamines bind to nucleic acids and their function is regulated by reversible acetylation. Here, the authors show that histone deacetylase 10 is a polyamine deacetylase and present its crystal structure with a bound polyamine transition state analogue inhibitor.
format	article
author	Yang Hai Stephen A. Shinsky Nicholas J. Porter David W. Christianson
author_facet	Yang Hai Stephen A. Shinsky Nicholas J. Porter David W. Christianson
author_sort	Yang Hai
title	Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
title_short	Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
title_full	Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
title_fullStr	Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
title_full_unstemmed	Histone deacetylase 10 structure and molecular function as a polyamine deacetylase
title_sort	histone deacetylase 10 structure and molecular function as a polyamine deacetylase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a275abbed63b43529d75e158a00c61cf
work_keys_str_mv	AT yanghai histonedeacetylase10structureandmolecularfunctionasapolyaminedeacetylase AT stephenashinsky histonedeacetylase10structureandmolecularfunctionasapolyaminedeacetylase AT nicholasjporter histonedeacetylase10structureandmolecularfunctionasapolyaminedeacetylase AT davidwchristianson histonedeacetylase10structureandmolecularfunctionasapolyaminedeacetylase
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Histone deacetylase 10 structure and molecular function as a polyamine deacetylase

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