Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma via Mitochondrial-Mediated Apoptosis

Oral squamous cell carcinoma (OSCC) predominantly consists of squamous cells and is the tumor with the highest incidence of the head and neck. Carnosic acid (CA), a natural monomer drug obtained from rosemary and salvia, shows various pharmacological effects, including of tumor development. This stu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fenghe Min, Xin Liu, Yuan Li, Mingyuan Dong, Yidi Qu, Weiwei Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	carnosic acid oral squamous cell carcinoma reactive oxygen species mitochondria apoptosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a2762edf90984228a10d49ea79095540
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a2762edf90984228a10d49ea79095540
record_format	dspace
spelling	oai:doaj.org-article:a2762edf90984228a10d49ea790955402021-12-01T07:40:49ZCarnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma via Mitochondrial-Mediated Apoptosis2234-943X10.3389/fonc.2021.760861https://doaj.org/article/a2762edf90984228a10d49ea790955402021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.760861/fullhttps://doaj.org/toc/2234-943XOral squamous cell carcinoma (OSCC) predominantly consists of squamous cells and is the tumor with the highest incidence of the head and neck. Carnosic acid (CA), a natural monomer drug obtained from rosemary and salvia, shows various pharmacological effects, including of tumor development. This study aimed to assess for an effect of CA on the development of OSCC and the underlying mechanisms. In CAL27 and SCC9 cells, CA inhibited cell proliferation and migration, increased intracellular levels of reactive oxygen species (ROS) and Ca2+, decreased the mitochondrial membrane potential (MMP), and promoted apoptosis. In CAL27- and SCC9-xenotransplanted BALB/c nude mice, CA inhibited the tumor growth without affecting the body weight and tissue morphology. CA upregulated Bax, Bad, cleaved Caspase-3 and -9 levels, and the cleaved PARP1/PARP1 ratio but downregulated Bcl-2 in CA-treated OSCC cells and OSCC cells-xenotransplanted BALB/c nude mice. These results indicate that CA suppresses OSCC at least via the mitochondrial apoptotic pathway and offers this natural compound as a potential therapeutic against OSCC.Fenghe MinFenghe MinFenghe MinXin LiuYuan LiMingyuan DongYidi QuWeiwei LiuWeiwei LiuFrontiers Media S.A.articlecarnosic acidoral squamous cell carcinomareactive oxygen speciesmitochondriaapoptosisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carnosic acid oral squamous cell carcinoma reactive oxygen species mitochondria apoptosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	carnosic acid oral squamous cell carcinoma reactive oxygen species mitochondria apoptosis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Fenghe Min Fenghe Min Fenghe Min Xin Liu Yuan Li Mingyuan Dong Yidi Qu Weiwei Liu Weiwei Liu Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma via Mitochondrial-Mediated Apoptosis
description	Oral squamous cell carcinoma (OSCC) predominantly consists of squamous cells and is the tumor with the highest incidence of the head and neck. Carnosic acid (CA), a natural monomer drug obtained from rosemary and salvia, shows various pharmacological effects, including of tumor development. This study aimed to assess for an effect of CA on the development of OSCC and the underlying mechanisms. In CAL27 and SCC9 cells, CA inhibited cell proliferation and migration, increased intracellular levels of reactive oxygen species (ROS) and Ca2+, decreased the mitochondrial membrane potential (MMP), and promoted apoptosis. In CAL27- and SCC9-xenotransplanted BALB/c nude mice, CA inhibited the tumor growth without affecting the body weight and tissue morphology. CA upregulated Bax, Bad, cleaved Caspase-3 and -9 levels, and the cleaved PARP1/PARP1 ratio but downregulated Bcl-2 in CA-treated OSCC cells and OSCC cells-xenotransplanted BALB/c nude mice. These results indicate that CA suppresses OSCC at least via the mitochondrial apoptotic pathway and offers this natural compound as a potential therapeutic against OSCC.
format	article
author	Fenghe Min Fenghe Min Fenghe Min Xin Liu Yuan Li Mingyuan Dong Yidi Qu Weiwei Liu Weiwei Liu
author_facet	Fenghe Min Fenghe Min Fenghe Min Xin Liu Yuan Li Mingyuan Dong Yidi Qu Weiwei Liu Weiwei Liu
author_sort	Fenghe Min
title	Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma via Mitochondrial-Mediated Apoptosis
title_short	Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma via Mitochondrial-Mediated Apoptosis
title_full	Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma via Mitochondrial-Mediated Apoptosis
title_fullStr	Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma via Mitochondrial-Mediated Apoptosis
title_full_unstemmed	Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma via Mitochondrial-Mediated Apoptosis
title_sort	carnosic acid suppresses the development of oral squamous cell carcinoma via mitochondrial-mediated apoptosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a2762edf90984228a10d49ea79095540
work_keys_str_mv	AT fenghemin carnosicacidsuppressesthedevelopmentoforalsquamouscellcarcinomaviamitochondrialmediatedapoptosis AT fenghemin carnosicacidsuppressesthedevelopmentoforalsquamouscellcarcinomaviamitochondrialmediatedapoptosis AT fenghemin carnosicacidsuppressesthedevelopmentoforalsquamouscellcarcinomaviamitochondrialmediatedapoptosis AT xinliu carnosicacidsuppressesthedevelopmentoforalsquamouscellcarcinomaviamitochondrialmediatedapoptosis AT yuanli carnosicacidsuppressesthedevelopmentoforalsquamouscellcarcinomaviamitochondrialmediatedapoptosis AT mingyuandong carnosicacidsuppressesthedevelopmentoforalsquamouscellcarcinomaviamitochondrialmediatedapoptosis AT yidiqu carnosicacidsuppressesthedevelopmentoforalsquamouscellcarcinomaviamitochondrialmediatedapoptosis AT weiweiliu carnosicacidsuppressesthedevelopmentoforalsquamouscellcarcinomaviamitochondrialmediatedapoptosis AT weiweiliu carnosicacidsuppressesthedevelopmentoforalsquamouscellcarcinomaviamitochondrialmediatedapoptosis
_version_	1718405430673145856

Carnosic Acid Suppresses the Development of Oral Squamous Cell Carcinoma via Mitochondrial-Mediated Apoptosis

Ejemplares similares