Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex

Binaural hearing is critically important for the perception of sound spatial locations. The primary auditory cortex (AI) has been demonstrated to be necessary for sound localization. However, after hearing onset, how the processing of binaural cues by AI neurons develops, and how the binaural proces...

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Autores principales:	Jing Liu, Xinyi Huang, Jiping Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	unilateral conductive hearing loss binaural processing binaural interaction auditory cortex interaural level differences rats Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/a279e888da49400181b996a3345fa886
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spelling	oai:doaj.org-article:a279e888da49400181b996a3345fa8862021-11-19T07:10:03ZUnilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex1662-453X10.3389/fnins.2021.762337https://doaj.org/article/a279e888da49400181b996a3345fa8862021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.762337/fullhttps://doaj.org/toc/1662-453XBinaural hearing is critically important for the perception of sound spatial locations. The primary auditory cortex (AI) has been demonstrated to be necessary for sound localization. However, after hearing onset, how the processing of binaural cues by AI neurons develops, and how the binaural processing of AI neurons is affected by reversible unilateral conductive hearing loss (RUCHL), are not fully elucidated. Here, we determined the binaural processing of AI neurons in four groups of rats: postnatal day (P) 14–18 rats, P19–30 rats, P57–70 adult rats, and RUCHL rats (P57–70) with RUCHL during P14–30. We recorded the responses of AI neurons to both monaural and binaural stimuli with variations in interaural level differences (ILDs) and average binaural levels. We found that the monaural response types, the binaural interaction types, and the distributions of the best ILDs of AI neurons in P14–18 rats are already adult-like. However, after hearing onset, there exist developmental refinements in the binaural processing of AI neurons, which are exhibited by the increase in the degree of binaural interaction, and the increase in the sensitivity and selectivity to ILDs. RUCHL during early hearing development affects monaural response types, decreases the degree of binaural interactions, and decreases both the selectivity and sensitivity to ILDs of AI neurons in adulthood. These new evidences help us to understand the refinements and plasticity in the binaural processing of AI neurons during hearing development, and might enhance our understanding in the neuronal mechanism of developmental changes in auditory spatial perception.Jing LiuXinyi HuangJiping ZhangFrontiers Media S.A.articleunilateral conductive hearing lossbinaural processingbinaural interactionauditory cortexinteraural level differencesratsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	unilateral conductive hearing loss binaural processing binaural interaction auditory cortex interaural level differences rats Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	unilateral conductive hearing loss binaural processing binaural interaction auditory cortex interaural level differences rats Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jing Liu Xinyi Huang Jiping Zhang Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex
description	Binaural hearing is critically important for the perception of sound spatial locations. The primary auditory cortex (AI) has been demonstrated to be necessary for sound localization. However, after hearing onset, how the processing of binaural cues by AI neurons develops, and how the binaural processing of AI neurons is affected by reversible unilateral conductive hearing loss (RUCHL), are not fully elucidated. Here, we determined the binaural processing of AI neurons in four groups of rats: postnatal day (P) 14–18 rats, P19–30 rats, P57–70 adult rats, and RUCHL rats (P57–70) with RUCHL during P14–30. We recorded the responses of AI neurons to both monaural and binaural stimuli with variations in interaural level differences (ILDs) and average binaural levels. We found that the monaural response types, the binaural interaction types, and the distributions of the best ILDs of AI neurons in P14–18 rats are already adult-like. However, after hearing onset, there exist developmental refinements in the binaural processing of AI neurons, which are exhibited by the increase in the degree of binaural interaction, and the increase in the sensitivity and selectivity to ILDs. RUCHL during early hearing development affects monaural response types, decreases the degree of binaural interactions, and decreases both the selectivity and sensitivity to ILDs of AI neurons in adulthood. These new evidences help us to understand the refinements and plasticity in the binaural processing of AI neurons during hearing development, and might enhance our understanding in the neuronal mechanism of developmental changes in auditory spatial perception.
format	article
author	Jing Liu Xinyi Huang Jiping Zhang
author_facet	Jing Liu Xinyi Huang Jiping Zhang
author_sort	Jing Liu
title	Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex
title_short	Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex
title_full	Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex
title_fullStr	Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex
title_full_unstemmed	Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex
title_sort	unilateral conductive hearing loss disrupts the developmental refinement of binaural processing in the rat primary auditory cortex
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a279e888da49400181b996a3345fa886
work_keys_str_mv	AT jingliu unilateralconductivehearinglossdisruptsthedevelopmentalrefinementofbinauralprocessingintheratprimaryauditorycortex AT xinyihuang unilateralconductivehearinglossdisruptsthedevelopmentalrefinementofbinauralprocessingintheratprimaryauditorycortex AT jipingzhang unilateralconductivehearinglossdisruptsthedevelopmentalrefinementofbinauralprocessingintheratprimaryauditorycortex
_version_	1718420330975854592

Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex

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