Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system

Abstract Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new approach to rapidly manipulate and evaluate the redox st...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Weng Kung Peng, Lan Chen, Bernhard O. Boehm, Jongyoon Han, Tze Ping Loh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/a27c8489bae24e1dbc493dea8d2fea60
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a27c8489bae24e1dbc493dea8d2fea60
record_format	dspace
spelling	oai:doaj.org-article:a27c8489bae24e1dbc493dea8d2fea602021-12-02T17:13:15ZMolecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system10.1038/s41514-020-00049-02056-3973https://doaj.org/article/a27c8489bae24e1dbc493dea8d2fea602020-10-01T00:00:00Zhttps://doi.org/10.1038/s41514-020-00049-0https://doaj.org/toc/2056-3973Abstract Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new approach to rapidly manipulate and evaluate the redox states of blood using a point-of-care NMR system. Various redox states of the hemoglobin were mapped out using the newly proposed (pseudo) two-dimensional map known as T 1–T 2 magnetic state diagram. We exploit the fact that oxidative stress changes the subtle molecular motion of water proton in the blood, and thus inducing a measurable shift in magnetic resonance relaxation properties. We demonstrated the clinical utilities of this technique to rapidly stratify diabetes subjects based on their oxidative status in conjunction to the traditional glycemic level to improve the patient stratification and thus the overall outcome of clinical diabetes care and management.Weng Kung PengLan ChenBernhard O. BoehmJongyoon HanTze Ping LohNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 6, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Weng Kung Peng Lan Chen Bernhard O. Boehm Jongyoon Han Tze Ping Loh Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
description	Abstract Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new approach to rapidly manipulate and evaluate the redox states of blood using a point-of-care NMR system. Various redox states of the hemoglobin were mapped out using the newly proposed (pseudo) two-dimensional map known as T 1–T 2 magnetic state diagram. We exploit the fact that oxidative stress changes the subtle molecular motion of water proton in the blood, and thus inducing a measurable shift in magnetic resonance relaxation properties. We demonstrated the clinical utilities of this technique to rapidly stratify diabetes subjects based on their oxidative status in conjunction to the traditional glycemic level to improve the patient stratification and thus the overall outcome of clinical diabetes care and management.
format	article
author	Weng Kung Peng Lan Chen Bernhard O. Boehm Jongyoon Han Tze Ping Loh
author_facet	Weng Kung Peng Lan Chen Bernhard O. Boehm Jongyoon Han Tze Ping Loh
author_sort	Weng Kung Peng
title	Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
title_short	Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
title_full	Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
title_fullStr	Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
title_full_unstemmed	Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
title_sort	molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care nmr system
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a27c8489bae24e1dbc493dea8d2fea60
work_keys_str_mv	AT wengkungpeng molecularphenotypingofoxidativestressindiabetesmellituswithpointofcarenmrsystem AT lanchen molecularphenotypingofoxidativestressindiabetesmellituswithpointofcarenmrsystem AT bernhardoboehm molecularphenotypingofoxidativestressindiabetesmellituswithpointofcarenmrsystem AT jongyoonhan molecularphenotypingofoxidativestressindiabetesmellituswithpointofcarenmrsystem AT tzepingloh molecularphenotypingofoxidativestressindiabetesmellituswithpointofcarenmrsystem
_version_	1718381395433226240

Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system

Ejemplares similares