Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c.

<h4>Objective</h4>To examine whether serum uric acid (SUA) is associated with 2-hour postload glucose (2-h PG) in Chinese with impaired fasting plasma glucose (IFG) and/or HbA1c (IA1C).<h4>Research design and methods</h4>Anthropometric and biochemical examinations, such as SU...

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Autores principales:	Hong-Qi Fan, Wei Tang, Zhi-Xiao Wang, Su-Juan Wang, Yue-Hua Qin, Qi Fu, Yuan Gao, Min Sun, Mei Zhang, Hong-Wen Zhou, Tao Yang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a27cac1a90354147a559903c1e34a2de
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spelling	oai:doaj.org-article:a27cac1a90354147a559903c1e34a2de2021-11-18T07:38:48ZAssociation of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c.1932-620310.1371/journal.pone.0067759https://doaj.org/article/a27cac1a90354147a559903c1e34a2de2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23844086/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To examine whether serum uric acid (SUA) is associated with 2-hour postload glucose (2-h PG) in Chinese with impaired fasting plasma glucose (IFG) and/or HbA1c (IA1C).<h4>Research design and methods</h4>Anthropometric and biochemical examinations, such as SUA concentration, were performed in 3763 individuals from all the villages in Baqiao County, China. A 75-g oral glucose tolerance test (OGTT) was conducted in 1197 Chinese with prediabetes as having IFG (110 ≤ fasting plasma glucose [FPG] <126 mg/dl and HbA1c <6.5%), IA1C (5.7% ≤ HbA1c <6.5% and FPG <126 mg/dl), or both.<h4>Results</h4>The present study included 1197 participants with IFG and/or IA1C (mean age 56.5 ± 10.3 years; 50.6% men). In multivariate linear regression, after adjustment for gender, age, smoking and drinking, body mass index (BMI), systolic and diastolic blood pressure (SBP, DBP), lipid profiles, logarithmic transformed C-reactive protein (log-CRP), estimated glomerular filtration rate (e-GFR), FPG and HbA1c, with a 1-mg/dl increment of SUA, 2-h PG increased by 5.04 ± 0.72 (P<0.001), 3.06 ± 1.08 (P = 0.001), 5.40 ± 1.26 (P<0.001), and 2.34 ± 2.16 mg/dl (P = 0.056) in all participants, in participants with normal glucose tolerance (NGT), with impaired glucose tolerance (IGT), and with 2-h newly diagnosed diabetes (2-h NDM, with 2-h PG ≥ 200 mg/dl), respectively. In both men and women, 2-h PG increased progressively and significantly from the lower to the upper SUA tertiles (P<0.001). Moreover, in multivariate logistic regression, 1-standard deviation (SD; 1.53 mg/dl) increment of SUA was significantly associated with a 36% higher risk for 2-h NDM (Odds ratio [CI 95%]: 1.36 [1.09-1.99]; P = 0.03).<h4>Conclusions</h4>SUA is significantly associated with 2-h PG in Chinese with IFG and/or IA1C.Hong-Qi FanWei TangZhi-Xiao WangSu-Juan WangYue-Hua QinQi FuYuan GaoMin SunMei ZhangHong-Wen ZhouTao YangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e67759 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hong-Qi Fan Wei Tang Zhi-Xiao Wang Su-Juan Wang Yue-Hua Qin Qi Fu Yuan Gao Min Sun Mei Zhang Hong-Wen Zhou Tao Yang Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c.
description	<h4>Objective</h4>To examine whether serum uric acid (SUA) is associated with 2-hour postload glucose (2-h PG) in Chinese with impaired fasting plasma glucose (IFG) and/or HbA1c (IA1C).<h4>Research design and methods</h4>Anthropometric and biochemical examinations, such as SUA concentration, were performed in 3763 individuals from all the villages in Baqiao County, China. A 75-g oral glucose tolerance test (OGTT) was conducted in 1197 Chinese with prediabetes as having IFG (110 ≤ fasting plasma glucose [FPG] <126 mg/dl and HbA1c <6.5%), IA1C (5.7% ≤ HbA1c <6.5% and FPG <126 mg/dl), or both.<h4>Results</h4>The present study included 1197 participants with IFG and/or IA1C (mean age 56.5 ± 10.3 years; 50.6% men). In multivariate linear regression, after adjustment for gender, age, smoking and drinking, body mass index (BMI), systolic and diastolic blood pressure (SBP, DBP), lipid profiles, logarithmic transformed C-reactive protein (log-CRP), estimated glomerular filtration rate (e-GFR), FPG and HbA1c, with a 1-mg/dl increment of SUA, 2-h PG increased by 5.04 ± 0.72 (P<0.001), 3.06 ± 1.08 (P = 0.001), 5.40 ± 1.26 (P<0.001), and 2.34 ± 2.16 mg/dl (P = 0.056) in all participants, in participants with normal glucose tolerance (NGT), with impaired glucose tolerance (IGT), and with 2-h newly diagnosed diabetes (2-h NDM, with 2-h PG ≥ 200 mg/dl), respectively. In both men and women, 2-h PG increased progressively and significantly from the lower to the upper SUA tertiles (P<0.001). Moreover, in multivariate logistic regression, 1-standard deviation (SD; 1.53 mg/dl) increment of SUA was significantly associated with a 36% higher risk for 2-h NDM (Odds ratio [CI 95%]: 1.36 [1.09-1.99]; P = 0.03).<h4>Conclusions</h4>SUA is significantly associated with 2-h PG in Chinese with IFG and/or IA1C.
format	article
author	Hong-Qi Fan Wei Tang Zhi-Xiao Wang Su-Juan Wang Yue-Hua Qin Qi Fu Yuan Gao Min Sun Mei Zhang Hong-Wen Zhou Tao Yang
author_facet	Hong-Qi Fan Wei Tang Zhi-Xiao Wang Su-Juan Wang Yue-Hua Qin Qi Fu Yuan Gao Min Sun Mei Zhang Hong-Wen Zhou Tao Yang
author_sort	Hong-Qi Fan
title	Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c.
title_short	Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c.
title_full	Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c.
title_fullStr	Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c.
title_full_unstemmed	Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c.
title_sort	association of serum uric acid with 2-hour postload glucose in chinese with impaired fasting plasma glucose and/or hba1c.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a27cac1a90354147a559903c1e34a2de
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Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c.

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