GASTROINTESTINAL STROMAL TUMORS (GIST): DIAGNOSIS AND TREATMENT

The article presents the analysis of diagnosis and treatment of 67 patients with gastrointestinal stromal tumors. The mostfrequent location was the stomach, the esophagus took the second place. Among the complications, gastrointestinal bleeding is leading, taking place in half of all cases. The tumo...

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Autores principales:	N. I. Bogomolov, P. P. Pakholchuk, N. N. Tomskikh, A. G. Goncharov, M. A. Goncharova, A. S. Golyakova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	tumor diagnostics surgery treatment Science Q
Acceso en línea:	https://doaj.org/article/a27d3323768049c2a123b8aa72abb3ed
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spelling	oai:doaj.org-article:a27d3323768049c2a123b8aa72abb3ed2021-11-23T06:14:39ZGASTROINTESTINAL STROMAL TUMORS (GIST): DIAGNOSIS AND TREATMENT2541-94202587-959610.12737/article_5a0a856cd0a467.14225823https://doaj.org/article/a27d3323768049c2a123b8aa72abb3ed2017-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/468https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article presents the analysis of diagnosis and treatment of 67 patients with gastrointestinal stromal tumors. The mostfrequent location was the stomach, the esophagus took the second place. Among the complications, gastrointestinal bleeding is leading, taking place in half of all cases. The tumor (GIST) develops from the interstitial cells of Cajal and is potentially malignant, the signs of which are established. The incidence of 1 million population is 10-20 cases. The expression of the proto-oncogene c-kit in GIST is detected by an immunohistochemical reaction with the CD117 marker. An erroneous diagnosis in a number of cases was a pseudocyst of the pancreas, found in a CT scan. Tumors bigger than 2 cm in diameter are subject to surgical treatment, smaller ones are recommended for dynamic observation. Organ-preservation operations without lymphodissection are considered acceptable in the course of surgical treatment. Target therapy with tyrosine kinase inhibitors (imatinib, sunitinib, etc.) is used. Two people received chemotherapy in the postoperative period. Histological examination of tumors in most cases detected spindle cell and epithelioid cell variants, in some cases there was a mixed version. GISTs remain the mostfrequent mesenchymal malignant neoplasms of the esophagus, stomach, small intestine, colon and rectum. The article demonstrates variants of GIST in 4 patients with localization of the process in the upper gastrointestinal tract, treatment options, when the final diagnosis was established during surgery with histological and histochemical studies.N. I. BogomolovP. P. PakholchukN. N. TomskikhA. G. GoncharovM. A. GoncharovaA. S. GolyakovaScientific Сentre for Family Health and Human Reproduction ProblemsarticletumordiagnosticssurgerytreatmentScienceQRUActa Biomedica Scientifica, Vol 2, Iss 6, Pp 52-58 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	tumor diagnostics surgery treatment Science Q
spellingShingle	tumor diagnostics surgery treatment Science Q N. I. Bogomolov P. P. Pakholchuk N. N. Tomskikh A. G. Goncharov M. A. Goncharova A. S. Golyakova GASTROINTESTINAL STROMAL TUMORS (GIST): DIAGNOSIS AND TREATMENT
description	The article presents the analysis of diagnosis and treatment of 67 patients with gastrointestinal stromal tumors. The mostfrequent location was the stomach, the esophagus took the second place. Among the complications, gastrointestinal bleeding is leading, taking place in half of all cases. The tumor (GIST) develops from the interstitial cells of Cajal and is potentially malignant, the signs of which are established. The incidence of 1 million population is 10-20 cases. The expression of the proto-oncogene c-kit in GIST is detected by an immunohistochemical reaction with the CD117 marker. An erroneous diagnosis in a number of cases was a pseudocyst of the pancreas, found in a CT scan. Tumors bigger than 2 cm in diameter are subject to surgical treatment, smaller ones are recommended for dynamic observation. Organ-preservation operations without lymphodissection are considered acceptable in the course of surgical treatment. Target therapy with tyrosine kinase inhibitors (imatinib, sunitinib, etc.) is used. Two people received chemotherapy in the postoperative period. Histological examination of tumors in most cases detected spindle cell and epithelioid cell variants, in some cases there was a mixed version. GISTs remain the mostfrequent mesenchymal malignant neoplasms of the esophagus, stomach, small intestine, colon and rectum. The article demonstrates variants of GIST in 4 patients with localization of the process in the upper gastrointestinal tract, treatment options, when the final diagnosis was established during surgery with histological and histochemical studies.
format	article
author	N. I. Bogomolov P. P. Pakholchuk N. N. Tomskikh A. G. Goncharov M. A. Goncharova A. S. Golyakova
author_facet	N. I. Bogomolov P. P. Pakholchuk N. N. Tomskikh A. G. Goncharov M. A. Goncharova A. S. Golyakova
author_sort	N. I. Bogomolov
title	GASTROINTESTINAL STROMAL TUMORS (GIST): DIAGNOSIS AND TREATMENT
title_short	GASTROINTESTINAL STROMAL TUMORS (GIST): DIAGNOSIS AND TREATMENT
title_full	GASTROINTESTINAL STROMAL TUMORS (GIST): DIAGNOSIS AND TREATMENT
title_fullStr	GASTROINTESTINAL STROMAL TUMORS (GIST): DIAGNOSIS AND TREATMENT
title_full_unstemmed	GASTROINTESTINAL STROMAL TUMORS (GIST): DIAGNOSIS AND TREATMENT
title_sort	gastrointestinal stromal tumors (gist): diagnosis and treatment
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/a27d3323768049c2a123b8aa72abb3ed
work_keys_str_mv	AT nibogomolov gastrointestinalstromaltumorsgistdiagnosisandtreatment AT pppakholchuk gastrointestinalstromaltumorsgistdiagnosisandtreatment AT nntomskikh gastrointestinalstromaltumorsgistdiagnosisandtreatment AT aggoncharov gastrointestinalstromaltumorsgistdiagnosisandtreatment AT magoncharova gastrointestinalstromaltumorsgistdiagnosisandtreatment AT asgolyakova gastrointestinalstromaltumorsgistdiagnosisandtreatment
_version_	1718416965246124032

GASTROINTESTINAL STROMAL TUMORS (GIST): DIAGNOSIS AND TREATMENT

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