Trazodone effects on [3H]-paroxetine and &alpha;2-adrenoreceptors in platelets of patients with major depression

Donatella Marazziti, Giorgio Consoli, Francesca Golia, Stefano Baroni, Irene Masala, Marina Carlini, Mario Catena Dell&rsquo;OssoDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, ItalyAbstract: Trazodone is an antidepressant which behaves as...

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Autores principales:	Donatella Marazziti, Giorgio Consoli, Francesca Golia, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a27dcdf0254745eca6004030733d4f49
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spelling	oai:doaj.org-article:a27dcdf0254745eca6004030733d4f492021-12-02T00:49:38ZTrazodone effects on [3H]-paroxetine and &alpha;2-adrenoreceptors in platelets of patients with major depression1176-63281178-2021https://doaj.org/article/a27dcdf0254745eca6004030733d4f492010-05-01T00:00:00Zhttp://www.dovepress.com/trazodone-effects-on-3h-paroxetine-and-alpha2-adrenoreceptors-in-plate-a4399https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Donatella Marazziti, Giorgio Consoli, Francesca Golia, Stefano Baroni, Irene Masala, Marina Carlini, Mario Catena Dell&rsquo;OssoDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, ItalyAbstract: Trazodone is an antidepressant which behaves as a selective 5-HT2 antagonist and 5-HT reuptake inhibitor. The lack of information on its effects in vivo prompted us to evaluate &alpha;2-adrenoceptors by means of the specific binding of [3H]-rauwolscine, and the 5-HT transporter (SERT) by means of the binding of [3H]-paroxetine ([3H]-Par), in platelets of depressed patients, before and after one month of treatment with trazodone (75&ndash;300 mg/day). Twenty-five outpatients of both sexes with a diagnosis of major depression, as assessed by the Structured Clinical Interview for DSM IV, were included in the study. Depressive symptoms were evaluated by means of the Hamilton Rating Scale for Depression: the total score (mean &plusmn; SD) was 20 &plusmn; 6 at baseline (t0) and 7 &plusmn; 4 after one month of treatment (t1). Platelet membranes, [3H]-rauwolscine and [3H]-Par bindings were carried out according to standardized protocols. The results showed that the Bmax values of [3H]-Par were statistically lower at t1 than at t0 (733 &plusmn; 30 vs 1471 &plusmn; 99, P &lt; 0.001), while the Kd and the [3H]-rauwolscine binding parameters remained unchanged. The findings of this study suggest that in vivo trazodone modifies the number of the SERT proteins and that, perhaps, most of its antidepressant properties are related to this activity.Keywords: trazodone, depression, serotonin, platelets, &alpha;2-adrenoreceptors, [3H]-rauwolscine, serotonin transporter, [3H]-paroxetine Donatella MarazzitiGiorgio ConsoliFrancesca Goliaet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 255-259 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Donatella Marazziti Giorgio Consoli Francesca Golia et al Trazodone effects on [3H]-paroxetine and &alpha;2-adrenoreceptors in platelets of patients with major depression
description	Donatella Marazziti, Giorgio Consoli, Francesca Golia, Stefano Baroni, Irene Masala, Marina Carlini, Mario Catena Dell&rsquo;OssoDipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Pisa, ItalyAbstract: Trazodone is an antidepressant which behaves as a selective 5-HT2 antagonist and 5-HT reuptake inhibitor. The lack of information on its effects in vivo prompted us to evaluate &alpha;2-adrenoceptors by means of the specific binding of [3H]-rauwolscine, and the 5-HT transporter (SERT) by means of the binding of [3H]-paroxetine ([3H]-Par), in platelets of depressed patients, before and after one month of treatment with trazodone (75&ndash;300 mg/day). Twenty-five outpatients of both sexes with a diagnosis of major depression, as assessed by the Structured Clinical Interview for DSM IV, were included in the study. Depressive symptoms were evaluated by means of the Hamilton Rating Scale for Depression: the total score (mean &plusmn; SD) was 20 &plusmn; 6 at baseline (t0) and 7 &plusmn; 4 after one month of treatment (t1). Platelet membranes, [3H]-rauwolscine and [3H]-Par bindings were carried out according to standardized protocols. The results showed that the Bmax values of [3H]-Par were statistically lower at t1 than at t0 (733 &plusmn; 30 vs 1471 &plusmn; 99, P &lt; 0.001), while the Kd and the [3H]-rauwolscine binding parameters remained unchanged. The findings of this study suggest that in vivo trazodone modifies the number of the SERT proteins and that, perhaps, most of its antidepressant properties are related to this activity.Keywords: trazodone, depression, serotonin, platelets, &alpha;2-adrenoreceptors, [3H]-rauwolscine, serotonin transporter, [3H]-paroxetine
format	article
author	Donatella Marazziti Giorgio Consoli Francesca Golia et al
author_facet	Donatella Marazziti Giorgio Consoli Francesca Golia et al
author_sort	Donatella Marazziti
title	Trazodone effects on [3H]-paroxetine and &alpha;2-adrenoreceptors in platelets of patients with major depression
title_short	Trazodone effects on [3H]-paroxetine and &alpha;2-adrenoreceptors in platelets of patients with major depression
title_full	Trazodone effects on [3H]-paroxetine and &alpha;2-adrenoreceptors in platelets of patients with major depression
title_fullStr	Trazodone effects on [3H]-paroxetine and &alpha;2-adrenoreceptors in platelets of patients with major depression
title_full_unstemmed	Trazodone effects on [3H]-paroxetine and &alpha;2-adrenoreceptors in platelets of patients with major depression
title_sort	trazodone effects on [3h]-paroxetine and &alpha;2-adrenoreceptors in platelets of patients with major depression
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/a27dcdf0254745eca6004030733d4f49
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Trazodone effects on [3H]-paroxetine and &amp;alpha;2-adrenoreceptors in platelets of patients with major depression

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