Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining

Detection of antigen specificity in a blood sample is limited by low frequencies of individual clones. Here the authors develop an MHC class II combinatorial technique and apply it to immunophenotype human CD4+ T cells of multiple specificities in response to influenza vaccine in single blood sample...

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Autores principales: Hannes Uchtenhagen, Cliff Rims, Gabriele Blahnik, I-Ting Chow, William W. Kwok, Jane H. Buckner, Eddie A. James
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/a2822371a2184c1581f604ee30e21895
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