The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein

Abstract Long-term studies have shown that virus infection affects the energy metabolism of host cells, which mainly affects the function of mitochondria and leads to the hydrolysis of ATP in host cells, but it is not clear how virus infection participates in mitochondrial energy metabolism in host...

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Autores principales:	Shiyu Li, Shuting Liu, Zhenning Dai, Qian Zhang, Yichao Xu, Youyu Chen, Zhenyou Jiang, Wenhua Huang, Hanxiao Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a2840742aa33408c865cc01f71dea200
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spelling	oai:doaj.org-article:a2840742aa33408c865cc01f71dea2002021-12-02T15:40:00ZThe UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein10.1038/s41598-021-93430-22045-2322https://doaj.org/article/a2840742aa33408c865cc01f71dea2002021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93430-2https://doaj.org/toc/2045-2322Abstract Long-term studies have shown that virus infection affects the energy metabolism of host cells, which mainly affects the function of mitochondria and leads to the hydrolysis of ATP in host cells, but it is not clear how virus infection participates in mitochondrial energy metabolism in host cells. In our study, HUVEC cells were infected with HSV-1, and the differentially expressed genes were obtained by microarray analysis and data analysis. The viral gene encoding protein UL16 was identified to interact with host protein ANT2 by immunoprecipitation and mass spectrometry. We also reported that UL16 transfection promoted oxidative phosphorylation of glucose and significantly increased intracellular ATP content. Furthermore, UL16 was transfected into the HUVEC cell model with mitochondrial dysfunction induced by d-Gal, and it was found that UL16 could restore the mitochondrial function of cells. It was first discovered that viral protein UL16 could enhance mitochondrial function in mammalian cells by promoting mitochondrial metabolism. This study provides a theoretical basis for the prevention and treatment of mitochondrial dysfunction or the pathological process related to mitochondrial dysfunction.Shiyu LiShuting LiuZhenning DaiQian ZhangYichao XuYouyu ChenZhenyou JiangWenhua HuangHanxiao SunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shiyu Li Shuting Liu Zhenning Dai Qian Zhang Yichao Xu Youyu Chen Zhenyou Jiang Wenhua Huang Hanxiao Sun The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein
description	Abstract Long-term studies have shown that virus infection affects the energy metabolism of host cells, which mainly affects the function of mitochondria and leads to the hydrolysis of ATP in host cells, but it is not clear how virus infection participates in mitochondrial energy metabolism in host cells. In our study, HUVEC cells were infected with HSV-1, and the differentially expressed genes were obtained by microarray analysis and data analysis. The viral gene encoding protein UL16 was identified to interact with host protein ANT2 by immunoprecipitation and mass spectrometry. We also reported that UL16 transfection promoted oxidative phosphorylation of glucose and significantly increased intracellular ATP content. Furthermore, UL16 was transfected into the HUVEC cell model with mitochondrial dysfunction induced by d-Gal, and it was found that UL16 could restore the mitochondrial function of cells. It was first discovered that viral protein UL16 could enhance mitochondrial function in mammalian cells by promoting mitochondrial metabolism. This study provides a theoretical basis for the prevention and treatment of mitochondrial dysfunction or the pathological process related to mitochondrial dysfunction.
format	article
author	Shiyu Li Shuting Liu Zhenning Dai Qian Zhang Yichao Xu Youyu Chen Zhenyou Jiang Wenhua Huang Hanxiao Sun
author_facet	Shiyu Li Shuting Liu Zhenning Dai Qian Zhang Yichao Xu Youyu Chen Zhenyou Jiang Wenhua Huang Hanxiao Sun
author_sort	Shiyu Li
title	The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein
title_short	The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein
title_full	The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein
title_fullStr	The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein
title_full_unstemmed	The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein
title_sort	ul16 protein of hsv-1 promotes the metabolism of cell mitochondria by binding to ant2 protein
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2840742aa33408c865cc01f71dea200
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The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein

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