Nrf2 Mutation/Activation Is Dispensable for the Development of Chemically Induced Mouse HCCSummary

Nrf2 Mutation/Activation Is Dispensable for the Development of Chemically Induced Mouse HCCSummary

Background & Aims: Activation of the kelch-like ECH-associated protein 1 (Keap1)–nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway has been associated with metabolic reprogramming in many tumors, including hepatocellular carcinoma (HCC). However, the contribution of Nrf2 mutations i...

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Main Authors: Sandra Mattu, Patrizia Zavattari, Marta Anna Kowalik, Marina Serra, Pia Sulas, Rajesh Pal, Elisabetta Puliga, Salvatore Sutti, Beatrice Foglia, Maurizio Parola, Emanuele Albano, Silvia Giordano, Andrea Perra, Amedeo Columbano
Format: article
Language:EN
Published: Elsevier 2022
Subjects:
Nrf2
Ctnnb1
Gene Mutation
Metabolic Reprogramming
HCC
Diseases of the digestive system. Gastroenterology
RC799-869
Online Access:https://doaj.org/article/a287ac6f649144fb9e8b07c7fac86783
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https://doaj.org/article/a287ac6f649144fb9e8b07c7fac86783

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