Prevalence of bacteriologically confirmed pulmonary tuberculosis and associated risk factors: A community survey in Thirvallur District, south India.

<h4>Background</h4>Tuberculosis (TB) prevalence surveys add to the active case detection in the community level burden of TB both national and regional levels. The aim of this study was to assess the prevalence of bacteriologically confirmed pulmonary tuberculosis (PTB) in the community....

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Autores principales:	Chandra Kumar Dolla, Bhaskaran Dhanaraj, Padmapriyadarsini Chandrasekaran, Sriram Selvaraj, Pradeep Aravindan Menon, Kannan Thiruvengadam, Rajendran Krishnan, Rajesh Mondal, Muniyandi Malaisamy, Srinivasa B Marinaik, Lakshmi Murali, Srikanth Prasad Tripathy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a287f65c55af485c85b3f2207a19e557
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spelling	oai:doaj.org-article:a287f65c55af485c85b3f2207a19e5572021-12-02T20:13:50ZPrevalence of bacteriologically confirmed pulmonary tuberculosis and associated risk factors: A community survey in Thirvallur District, south India.1932-620310.1371/journal.pone.0247245https://doaj.org/article/a287f65c55af485c85b3f2207a19e5572021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0247245https://doaj.org/toc/1932-6203<h4>Background</h4>Tuberculosis (TB) prevalence surveys add to the active case detection in the community level burden of TB both national and regional levels. The aim of this study was to assess the prevalence of bacteriologically confirmed pulmonary tuberculosis (PTB) in the community.<h4>Methods</h4>Household community-based tuberculosis disease survey was conducted targeting 69054 population from 43 villages of 5 blocks in Tiruvallure district adopting cluster sampling methodology of ≥15 years old adult rural population of South India during 2015-2018. All eligible individuals with suspected symptoms of PTB were screened with chest X-ray. Two sputum specimens (one spot and the other early morning sample) were collected for M.tb smear and culture examination. Conversely demographical, smoking and alcohol drinking habits information were also collected to explore the risk factor. Stepwise logistic regression was employed to associate risk factors for PTB.<h4>Results</h4>A total of 62494 were screened among 69054 eligible population, of whom 6340 were eligible for sputum specimen collection. Sputum for M.tb smear and culture examination were collected in 93% of participants. The derived prevalence of PTB was 307/100000 population (smear-positive 130; culture positive 277). As expected that PTB has decreased substantially compared to preceding surveys and it showed that older age, male, low BMI, diabetes, earlier history of TB and alcohol users were significantly associated (p < .0001) with an increased risk of developing PTB.<h4>Conclusion</h4>Upshot of the active survey has established a reduction in the prevalence of PTB in the rural area which can be accredited to better programmatic implementation and success of the National TB Control Programme in this district. It also has highlighted the need for risk reduction interventions accelerate faster elimination of TB.Chandra Kumar DollaBhaskaran DhanarajPadmapriyadarsini ChandrasekaranSriram SelvarajPradeep Aravindan MenonKannan ThiruvengadamRajendran KrishnanRajesh MondalMuniyandi MalaisamySrinivasa B MarinaikLakshmi MuraliSrikanth Prasad TripathyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0247245 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chandra Kumar Dolla Bhaskaran Dhanaraj Padmapriyadarsini Chandrasekaran Sriram Selvaraj Pradeep Aravindan Menon Kannan Thiruvengadam Rajendran Krishnan Rajesh Mondal Muniyandi Malaisamy Srinivasa B Marinaik Lakshmi Murali Srikanth Prasad Tripathy Prevalence of bacteriologically confirmed pulmonary tuberculosis and associated risk factors: A community survey in Thirvallur District, south India.
description	<h4>Background</h4>Tuberculosis (TB) prevalence surveys add to the active case detection in the community level burden of TB both national and regional levels. The aim of this study was to assess the prevalence of bacteriologically confirmed pulmonary tuberculosis (PTB) in the community.<h4>Methods</h4>Household community-based tuberculosis disease survey was conducted targeting 69054 population from 43 villages of 5 blocks in Tiruvallure district adopting cluster sampling methodology of ≥15 years old adult rural population of South India during 2015-2018. All eligible individuals with suspected symptoms of PTB were screened with chest X-ray. Two sputum specimens (one spot and the other early morning sample) were collected for M.tb smear and culture examination. Conversely demographical, smoking and alcohol drinking habits information were also collected to explore the risk factor. Stepwise logistic regression was employed to associate risk factors for PTB.<h4>Results</h4>A total of 62494 were screened among 69054 eligible population, of whom 6340 were eligible for sputum specimen collection. Sputum for M.tb smear and culture examination were collected in 93% of participants. The derived prevalence of PTB was 307/100000 population (smear-positive 130; culture positive 277). As expected that PTB has decreased substantially compared to preceding surveys and it showed that older age, male, low BMI, diabetes, earlier history of TB and alcohol users were significantly associated (p < .0001) with an increased risk of developing PTB.<h4>Conclusion</h4>Upshot of the active survey has established a reduction in the prevalence of PTB in the rural area which can be accredited to better programmatic implementation and success of the National TB Control Programme in this district. It also has highlighted the need for risk reduction interventions accelerate faster elimination of TB.
format	article
author	Chandra Kumar Dolla Bhaskaran Dhanaraj Padmapriyadarsini Chandrasekaran Sriram Selvaraj Pradeep Aravindan Menon Kannan Thiruvengadam Rajendran Krishnan Rajesh Mondal Muniyandi Malaisamy Srinivasa B Marinaik Lakshmi Murali Srikanth Prasad Tripathy
author_facet	Chandra Kumar Dolla Bhaskaran Dhanaraj Padmapriyadarsini Chandrasekaran Sriram Selvaraj Pradeep Aravindan Menon Kannan Thiruvengadam Rajendran Krishnan Rajesh Mondal Muniyandi Malaisamy Srinivasa B Marinaik Lakshmi Murali Srikanth Prasad Tripathy
author_sort	Chandra Kumar Dolla
title	Prevalence of bacteriologically confirmed pulmonary tuberculosis and associated risk factors: A community survey in Thirvallur District, south India.
title_short	Prevalence of bacteriologically confirmed pulmonary tuberculosis and associated risk factors: A community survey in Thirvallur District, south India.
title_full	Prevalence of bacteriologically confirmed pulmonary tuberculosis and associated risk factors: A community survey in Thirvallur District, south India.
title_fullStr	Prevalence of bacteriologically confirmed pulmonary tuberculosis and associated risk factors: A community survey in Thirvallur District, south India.
title_full_unstemmed	Prevalence of bacteriologically confirmed pulmonary tuberculosis and associated risk factors: A community survey in Thirvallur District, south India.
title_sort	prevalence of bacteriologically confirmed pulmonary tuberculosis and associated risk factors: a community survey in thirvallur district, south india.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a287f65c55af485c85b3f2207a19e557
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Prevalence of bacteriologically confirmed pulmonary tuberculosis and associated risk factors: A community survey in Thirvallur District, south India.

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