Early Detection and Investigation of Extracellular Vesicles Biomarkers in Breast Cancer

Breast cancer (BC) is the most commonly diagnosed malignant tumor in women worldwide, and the leading cause of cancer death in the female population. The percentage of patients experiencing poor prognosis along with the risk of developing metastasis remains high, also affecting the resistance to cur...

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Autores principales:	Erika Bandini, Tania Rossi, Emanuela Scarpi, Giulia Gallerani, Ivan Vannini, Samanta Salvi, Irene Azzali, Mattia Melloni, Sara Salucci, Michela Battistelli, Patrizia Serra, Roberta Maltoni, William C. Cho, Francesco Fabbri
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	breast cancer extracellular vesicles plasma liquid biopsy biomarkers Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a2883136b93b4a32a4c6096fa762fe88
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spelling	oai:doaj.org-article:a2883136b93b4a32a4c6096fa762fe882021-11-08T05:15:59ZEarly Detection and Investigation of Extracellular Vesicles Biomarkers in Breast Cancer2296-889X10.3389/fmolb.2021.732900https://doaj.org/article/a2883136b93b4a32a4c6096fa762fe882021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.732900/fullhttps://doaj.org/toc/2296-889XBreast cancer (BC) is the most commonly diagnosed malignant tumor in women worldwide, and the leading cause of cancer death in the female population. The percentage of patients experiencing poor prognosis along with the risk of developing metastasis remains high, also affecting the resistance to current main therapies. Cancer progression and metastatic development are no longer due entirely to their intrinsic characteristics, but also regulated by signals derived from cells of the tumor microenvironment. Extracellular vesicles (EVs) packed with DNA, RNA, and proteins, are the most attractive targets for both diagnostic and therapeutic applications, and represent a decisive challenge as liquid biopsy-based markers. Here we performed a study based on a multiplexed phenotyping flow cytometric approach to characterize BC-derived EVs from BC patients and cell lines, through the detection of multiple antigens. Our data reveal the expression of EVs-related biomarkers derived from BC patient plasma and cell line supernatants, suggesting that EVs could be exploited for characterizing and monitoring disease progression.Erika BandiniTania RossiEmanuela ScarpiGiulia GalleraniIvan VanniniSamanta SalviIrene AzzaliMattia MelloniSara SalucciMichela BattistelliPatrizia SerraRoberta MaltoniWilliam C. ChoFrancesco FabbriFrontiers Media S.A.articlebreast cancerextracellular vesiclesplasmaliquid biopsybiomarkersBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer extracellular vesicles plasma liquid biopsy biomarkers Biology (General) QH301-705.5
spellingShingle	breast cancer extracellular vesicles plasma liquid biopsy biomarkers Biology (General) QH301-705.5 Erika Bandini Tania Rossi Emanuela Scarpi Giulia Gallerani Ivan Vannini Samanta Salvi Irene Azzali Mattia Melloni Sara Salucci Michela Battistelli Patrizia Serra Roberta Maltoni William C. Cho Francesco Fabbri Early Detection and Investigation of Extracellular Vesicles Biomarkers in Breast Cancer
description	Breast cancer (BC) is the most commonly diagnosed malignant tumor in women worldwide, and the leading cause of cancer death in the female population. The percentage of patients experiencing poor prognosis along with the risk of developing metastasis remains high, also affecting the resistance to current main therapies. Cancer progression and metastatic development are no longer due entirely to their intrinsic characteristics, but also regulated by signals derived from cells of the tumor microenvironment. Extracellular vesicles (EVs) packed with DNA, RNA, and proteins, are the most attractive targets for both diagnostic and therapeutic applications, and represent a decisive challenge as liquid biopsy-based markers. Here we performed a study based on a multiplexed phenotyping flow cytometric approach to characterize BC-derived EVs from BC patients and cell lines, through the detection of multiple antigens. Our data reveal the expression of EVs-related biomarkers derived from BC patient plasma and cell line supernatants, suggesting that EVs could be exploited for characterizing and monitoring disease progression.
format	article
author	Erika Bandini Tania Rossi Emanuela Scarpi Giulia Gallerani Ivan Vannini Samanta Salvi Irene Azzali Mattia Melloni Sara Salucci Michela Battistelli Patrizia Serra Roberta Maltoni William C. Cho Francesco Fabbri
author_facet	Erika Bandini Tania Rossi Emanuela Scarpi Giulia Gallerani Ivan Vannini Samanta Salvi Irene Azzali Mattia Melloni Sara Salucci Michela Battistelli Patrizia Serra Roberta Maltoni William C. Cho Francesco Fabbri
author_sort	Erika Bandini
title	Early Detection and Investigation of Extracellular Vesicles Biomarkers in Breast Cancer
title_short	Early Detection and Investigation of Extracellular Vesicles Biomarkers in Breast Cancer
title_full	Early Detection and Investigation of Extracellular Vesicles Biomarkers in Breast Cancer
title_fullStr	Early Detection and Investigation of Extracellular Vesicles Biomarkers in Breast Cancer
title_full_unstemmed	Early Detection and Investigation of Extracellular Vesicles Biomarkers in Breast Cancer
title_sort	early detection and investigation of extracellular vesicles biomarkers in breast cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a2883136b93b4a32a4c6096fa762fe88
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Early Detection and Investigation of Extracellular Vesicles Biomarkers in Breast Cancer

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