Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

Organoid cultures have been developed from multiple tissues, opening new possibilities for regenerative medicine. Here the authors demonstrate the derivation of GMP-compliant hydrogels from decellularized porcine small intestine which support formation and growth of human gastric, liver, pancreatic...

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Autores principales:	Giovanni Giuseppe Giobbe, Claire Crowley, Camilla Luni, Sara Campinoti, Moustafa Khedr, Kai Kretzschmar, Martina Maria De Santis, Elisa Zambaiti, Federica Michielin, Laween Meran, Qianjiang Hu, Gijs van Son, Luca Urbani, Anna Manfredi, Monica Giomo, Simon Eaton, Davide Cacchiarelli, Vivian S. W. Li, Hans Clevers, Paola Bonfanti, Nicola Elvassore, Paolo De Coppi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a28b06f5539f456b97162079de3a5a5a
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spelling	oai:doaj.org-article:a28b06f5539f456b97162079de3a5a5a2021-12-02T15:35:58ZExtracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture10.1038/s41467-019-13605-42041-1723https://doaj.org/article/a28b06f5539f456b97162079de3a5a5a2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13605-4https://doaj.org/toc/2041-1723Organoid cultures have been developed from multiple tissues, opening new possibilities for regenerative medicine. Here the authors demonstrate the derivation of GMP-compliant hydrogels from decellularized porcine small intestine which support formation and growth of human gastric, liver, pancreatic and small intestinal organoids.Giovanni Giuseppe GiobbeClaire CrowleyCamilla LuniSara CampinotiMoustafa KhedrKai KretzschmarMartina Maria De SantisElisa ZambaitiFederica MichielinLaween MeranQianjiang HuGijs van SonLuca UrbaniAnna ManfrediMonica GiomoSimon EatonDavide CacchiarelliVivian S. W. LiHans CleversPaola BonfantiNicola ElvassorePaolo De CoppiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giovanni Giuseppe Giobbe Claire Crowley Camilla Luni Sara Campinoti Moustafa Khedr Kai Kretzschmar Martina Maria De Santis Elisa Zambaiti Federica Michielin Laween Meran Qianjiang Hu Gijs van Son Luca Urbani Anna Manfredi Monica Giomo Simon Eaton Davide Cacchiarelli Vivian S. W. Li Hans Clevers Paola Bonfanti Nicola Elvassore Paolo De Coppi Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture
description	Organoid cultures have been developed from multiple tissues, opening new possibilities for regenerative medicine. Here the authors demonstrate the derivation of GMP-compliant hydrogels from decellularized porcine small intestine which support formation and growth of human gastric, liver, pancreatic and small intestinal organoids.
format	article
author	Giovanni Giuseppe Giobbe Claire Crowley Camilla Luni Sara Campinoti Moustafa Khedr Kai Kretzschmar Martina Maria De Santis Elisa Zambaiti Federica Michielin Laween Meran Qianjiang Hu Gijs van Son Luca Urbani Anna Manfredi Monica Giomo Simon Eaton Davide Cacchiarelli Vivian S. W. Li Hans Clevers Paola Bonfanti Nicola Elvassore Paolo De Coppi
author_facet	Giovanni Giuseppe Giobbe Claire Crowley Camilla Luni Sara Campinoti Moustafa Khedr Kai Kretzschmar Martina Maria De Santis Elisa Zambaiti Federica Michielin Laween Meran Qianjiang Hu Gijs van Son Luca Urbani Anna Manfredi Monica Giomo Simon Eaton Davide Cacchiarelli Vivian S. W. Li Hans Clevers Paola Bonfanti Nicola Elvassore Paolo De Coppi
author_sort	Giovanni Giuseppe Giobbe
title	Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture
title_short	Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture
title_full	Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture
title_fullStr	Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture
title_full_unstemmed	Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture
title_sort	extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a28b06f5539f456b97162079de3a5a5a
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Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

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