Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models

Obesity and its associated metabolic changes, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Here, the authors show that restricting when mice eat, but not what or how much they eat, delays breast cancer...

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Autores principales:	Manasi Das, Lesley G. Ellies, Deepak Kumar, Consuelo Sauceda, Alexis Oberg, Emilie Gross, Tyler Mandt, Isabel G. Newton, Mehak Kaur, Dorothy D. Sears, Nicholas J. G. Webster
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a2944ae436f340f4a94b7c20729f5a09
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spelling	oai:doaj.org-article:a2944ae436f340f4a94b7c20729f5a092021-12-02T10:47:58ZTime-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models10.1038/s41467-020-20743-72041-1723https://doaj.org/article/a2944ae436f340f4a94b7c20729f5a092021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20743-7https://doaj.org/toc/2041-1723Obesity and its associated metabolic changes, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Here, the authors show that restricting when mice eat, but not what or how much they eat, delays breast cancer initiation and reduces tumor growth in obese mice in addition to improving insulin sensitivity and restoring circadian rhythms.Manasi DasLesley G. ElliesDeepak KumarConsuelo SaucedaAlexis ObergEmilie GrossTyler MandtIsabel G. NewtonMehak KaurDorothy D. SearsNicholas J. G. WebsterNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manasi Das Lesley G. Ellies Deepak Kumar Consuelo Sauceda Alexis Oberg Emilie Gross Tyler Mandt Isabel G. Newton Mehak Kaur Dorothy D. Sears Nicholas J. G. Webster Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
description	Obesity and its associated metabolic changes, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Here, the authors show that restricting when mice eat, but not what or how much they eat, delays breast cancer initiation and reduces tumor growth in obese mice in addition to improving insulin sensitivity and restoring circadian rhythms.
format	article
author	Manasi Das Lesley G. Ellies Deepak Kumar Consuelo Sauceda Alexis Oberg Emilie Gross Tyler Mandt Isabel G. Newton Mehak Kaur Dorothy D. Sears Nicholas J. G. Webster
author_facet	Manasi Das Lesley G. Ellies Deepak Kumar Consuelo Sauceda Alexis Oberg Emilie Gross Tyler Mandt Isabel G. Newton Mehak Kaur Dorothy D. Sears Nicholas J. G. Webster
author_sort	Manasi Das
title	Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
title_short	Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
title_full	Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
title_fullStr	Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
title_full_unstemmed	Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
title_sort	time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a2944ae436f340f4a94b7c20729f5a09
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Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models

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