Clearance of HIV infection by selective elimination of host cells capable of producing HIV

The latent human immunodeficiency virus (HIV) reservoir in patients poses a problem for HIV cure. Here, Li et al. show that a combination of compounds inducing viral reactivation and cell death, inhibiting autophagy and blocking new infections can eliminate HIV infection in 50% of humanized HIV infe...

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Autores principales:	Min Li, Wei Liu, Tonya Bauch, Edward A. Graviss, Roberto C. Arduino, Jason T. Kimata, Min Chen, Jin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a29698dadd944cffb50ce9cbf99bfd3a
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spelling	oai:doaj.org-article:a29698dadd944cffb50ce9cbf99bfd3a2021-12-02T15:07:56ZClearance of HIV infection by selective elimination of host cells capable of producing HIV10.1038/s41467-020-17753-w2041-1723https://doaj.org/article/a29698dadd944cffb50ce9cbf99bfd3a2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17753-whttps://doaj.org/toc/2041-1723The latent human immunodeficiency virus (HIV) reservoir in patients poses a problem for HIV cure. Here, Li et al. show that a combination of compounds inducing viral reactivation and cell death, inhibiting autophagy and blocking new infections can eliminate HIV infection in 50% of humanized HIV infected mice and in blood samples from infected patients.Min LiWei LiuTonya BauchEdward A. GravissRoberto C. ArduinoJason T. KimataMin ChenJin WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Min Li Wei Liu Tonya Bauch Edward A. Graviss Roberto C. Arduino Jason T. Kimata Min Chen Jin Wang Clearance of HIV infection by selective elimination of host cells capable of producing HIV
description	The latent human immunodeficiency virus (HIV) reservoir in patients poses a problem for HIV cure. Here, Li et al. show that a combination of compounds inducing viral reactivation and cell death, inhibiting autophagy and blocking new infections can eliminate HIV infection in 50% of humanized HIV infected mice and in blood samples from infected patients.
format	article
author	Min Li Wei Liu Tonya Bauch Edward A. Graviss Roberto C. Arduino Jason T. Kimata Min Chen Jin Wang
author_facet	Min Li Wei Liu Tonya Bauch Edward A. Graviss Roberto C. Arduino Jason T. Kimata Min Chen Jin Wang
author_sort	Min Li
title	Clearance of HIV infection by selective elimination of host cells capable of producing HIV
title_short	Clearance of HIV infection by selective elimination of host cells capable of producing HIV
title_full	Clearance of HIV infection by selective elimination of host cells capable of producing HIV
title_fullStr	Clearance of HIV infection by selective elimination of host cells capable of producing HIV
title_full_unstemmed	Clearance of HIV infection by selective elimination of host cells capable of producing HIV
title_sort	clearance of hiv infection by selective elimination of host cells capable of producing hiv
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a29698dadd944cffb50ce9cbf99bfd3a
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Clearance of HIV infection by selective elimination of host cells capable of producing HIV

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